| Fetal dopamine receptor characteristics assessed in utero. | |
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MedLine Citation:
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PMID: 20531464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Any tracer in fetal tissue comes from maternal arterial blood. Provided steady state is achieved and intermediate compartments are reversible, the Logan graphical methods should be applicable to the assessment of binding parameters in the fetal brain. Two pregnant rhesus macaques were studied with fallypride and the Logan method was used to assess dopamine receptor distribution volume ratios (DVRs) in both maternal and fetal striatum. The agreement between fetal striatal DVRs using maternal arterial blood and maternal and fetal cerebellum as input functions strongly supports our hypothesis that the conditions necessary for graphical analysis have been met. |
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Authors:
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Rachel M Bartlett; Onofre T Dejesus; Todd E Barnhart; R Jerome Nickles; Bradley T Christian; John L Graner; James E Holden |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-09 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-09-07 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1437-40 Citation Subset: IM |
Affiliation:
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Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzamides / diagnostic use* Corpus Striatum / metabolism*, radionuclide imaging Female Fetus / metabolism*, radionuclide imaging Macaca mulatta Positron-Emission Tomography / methods* Pregnancy Pyrrolidines / diagnostic use* Receptors, Dopamine / blood, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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T32 CA-09206-29/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; 0/Pyrrolidines; 0/Receptors, Dopamine |
| Comments/Corrections | |
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