Document Detail


Fetal dopamine receptor characteristics assessed in utero.
MedLine Citation:
PMID:  20531464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Any tracer in fetal tissue comes from maternal arterial blood. Provided steady state is achieved and intermediate compartments are reversible, the Logan graphical methods should be applicable to the assessment of binding parameters in the fetal brain. Two pregnant rhesus macaques were studied with fallypride and the Logan method was used to assess dopamine receptor distribution volume ratios (DVRs) in both maternal and fetal striatum. The agreement between fetal striatal DVRs using maternal arterial blood and maternal and fetal cerebellum as input functions strongly supports our hypothesis that the conditions necessary for graphical analysis have been met.
Authors:
Rachel M Bartlett; Onofre T Dejesus; Todd E Barnhart; R Jerome Nickles; Bradley T Christian; John L Graner; James E Holden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-06-09
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  30     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-09-07     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1437-40     Citation Subset:  IM    
Affiliation:
Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzamides / diagnostic use*
Corpus Striatum / metabolism*,  radionuclide imaging
Female
Fetus / metabolism*,  radionuclide imaging
Macaca mulatta
Positron-Emission Tomography / methods*
Pregnancy
Pyrrolidines / diagnostic use*
Receptors, Dopamine / blood,  metabolism*
Grant Support
ID/Acronym/Agency:
T32 CA-09206-29/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Benzamides; 0/N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; 0/Pyrrolidines; 0/Receptors, Dopamine
Comments/Corrections

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