| Fetal death as a result of placental immune reconstitution inflammatory syndrome. | |
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MedLine Citation:
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PMID: 20361998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 26-year-old woman was HIV-1 diagnosed at 11 weeks of pregnancy (CD4 = 7/mm(3), HIV-1 RNA = 108,000 copies/mL) with immunity against toxoplasmosis (Toxoplasma IgG = 1800 UI/mL). A fetal death was diagnosed 7 weeks after starting HAART (CD4 = 185/mm(3), HIV-1 RNA = 391 copies/mL) with a positive Toxoplasma PCR on fetal tissues and amniotic fluid. The absence of severe toxoplasmic foetopathy, the very exaggerated and atypical placental inflammation and the immune restoration context led to the diagnosis of placental IRIS associated with Toxoplasma gondii reactivation. This outcome remains undescribed and could represent an issue in resource-limited settings where HIV-pregnant patients are often severely immunodeficient and infected with opportunistic pathogens. |
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Authors:
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F Caby; D Lemercier; A Coulomb; R Grigorescu; L Paris; F Touafek; G Carcelain; A Canestri; M Pauchard; C Katlama; M Dommergues; R Tubiana |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-03-31 |
Journal Detail:
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Title: The Journal of infection Volume: 61 ISSN: 1532-2742 ISO Abbreviation: J. Infect. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7908424 Medline TA: J Infect Country: England |
Other Details:
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Languages: eng Pagination: 185-8 Citation Subset: IM |
Affiliation:
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Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Pitié-Salpêtrière, Assistance publique des hôpitaux de Paris (AP-HP), Paris, France. fabienne.caby@psl.aphp.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / parasitology Anti-HIV Agents / adverse effects, therapeutic use* Antiretroviral Therapy, Highly Active / adverse effects CD4 Lymphocyte Count DNA, Protozoan / isolation & purification Female Fetal Death* HIV Infections / complications*, drug therapy, virology HIV-1 / isolation & purification Humans Immune Reconstitution Inflammatory Syndrome / complications, diagnosis* Placenta / pathology Pregnancy Pregnancy Complications, Infectious / drug therapy* RNA, Viral / blood Toxoplasma / isolation & purification Toxoplasmosis / complications*, diagnosis*, parasitology Viral Load |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/DNA, Protozoan; 0/RNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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