Document Detail

Fetal constraint as a potential risk factor for craniosynostosis.
MedLine Citation:
PMID:  20101684     Owner:  NLM     Status:  MEDLINE    
Non-syndromic craniosynostosis is multifactorial, and fetal head constraint has been hypothesized as one factor thought to play a role. Data from the National Birth Defects Prevention Study (NBDPS), a large multi-site case-control study of birth defects, were used to evaluate associations between four selected factors related to fetal constraint and craniosynostosis: plurality (twins or higher), macrosomia (birth weight >4,000 g), post-term gestational age (> or =42 weeks), and nulliparity (no previous live births). Case infants (n = 675) had craniosynostosis documented either by radiographic evidence or by surgical intervention. Infants with a recognized or strongly suspected single-gene conditions or chromosomal abnormalities were excluded. Control infants (n = 5,958) had no major birth defects and were randomly selected from the same population as case infants. Logistic regression was used to estimate odds ratios for the association between these four factors and craniosynostosis, while adjusting for several covariates. We found that plurality and nulliparity were associated with a twofold increased risk for metopic craniosynostosis, and macrosomia had almost twice the risk of developing coronal craniosynostosis. Contrary to our hypothesis, prematurity and low birth weight were also associated with craniosynostosis. In conclusion, these four constraint-related factors were not found to be associated with craniosynostosis when all suture types were combined, though some types of craniosynostosis were associated with individual constraint-related factors.
Pedro A Sanchez-Lara; Suzan L Carmichael; John M Graham; Edward J Lammer; Gary M Shaw; Chen Ma; Sonja A Rasmussen;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of medical genetics. Part A     Volume:  152A     ISSN:  1552-4833     ISO Abbreviation:  Am. J. Med. Genet. A     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-02     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101235741     Medline TA:  Am J Med Genet A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  394-400     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Wiley-Liss, Inc.
Children's Hospital Los Angeles, Keck School of Medicine at University of Southern California, Los Angeles, California 90027, USA.
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MeSH Terms
Birth Weight
Case-Control Studies
Congenital Abnormalities / epidemiology,  genetics
Craniosynostoses / epidemiology,  etiology,  genetics*
Fetal Growth Retardation / epidemiology,  genetics*
Gestational Age
Infant, Newborn
Odds Ratio
Pregnancy Complications
Risk Factors
Grant Support
1U01DD000489-01/DD/NCBDD CDC HHS; 5-T32-GM08243/GM/NIGMS NIH HHS; HD22657/HD/NICHD NIH HHS; K12 HD052954-03/HD/NICHD NIH HHS; K12-HD05954/HD/NICHD NIH HHS; U50/CCU925286//PHS HHS

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