Document Detail

Fetal cleft lip repair in rabbits: postnatal facial growth after repair.
MedLine Citation:
PMID:  2037916     Owner:  NLM     Status:  MEDLINE    
We have previously described a model for in utero cleft lip repair in rabbits. Cleft lip and alveolus (CL) were created in fetal rabbits at 24 days gestation (term, 31 days). In this study, postnatal maxillary growth was evaluated in three groups of animals: 1) unoperated controls, 2) unrepaired CL, and 2) repaired CL. The animals were killed at 4, 12, and 26 weeks after birth. Direct cephalometry was performed on dry skulls to evaluate premaxillary width, anterior maxillary length and width, and posterior maxillary width. The results of this study indicate that rabbits that undergo an in utero CL procedure, with or without repair, exhibit no significant decrease in maxillary length and width when compared with controls.
T B Dodson; B Schmidt; M T Longaker; L B Kaban
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  49     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-28     Completed Date:  1991-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  603-11     Citation Subset:  AIM; D; IM    
Department of Oral and Maxillofacial Surgery, University of California San Francisco 94143-0440.
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MeSH Terms
Alveolar Process / abnormalities,  pathology
Cleft Lip / embryology*,  pathology,  surgery
Fetus / surgery*
Lip / pathology
Maxilla / pathology
Maxillofacial Development*
Nasal Bone / pathology
Nose / abnormalities,  pathology
Grant Support

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