Document Detail


Fetal cerebral metabolism: the influence of asphyxia and other factors.
MedLine Citation:
PMID:  7830153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral oxidative metabolism has been described in fetal sheep at two stages of development and is known to remain relatively constant over a wide range of oxygen levels in arterial blood. This constancy of oxygen consumption is caused by an increase in cerebral blood flow that matches the reduction in oxygen content and oxygen extraction. Although a number of factors are involved in the hypoxia-associated vasodilation (for example, oxygen, carbon dioxide, adenosine, prostaglandins, arginine vasopressin), its regulation is incompletely understood. During severe asphyxia, however, there is a limit to the vasodilator function, and both cerebral blood flow and oxygen consumption fall. The fetus can tolerate a certain degree of reduced oxygen uptake (possibly to 50% of control level) by various conservation techniques, but severe reductions are associated with neuronal damage. The primary substrate for the fetal brain under normal conditions is glucose, but the fetus can readily use anaerobic glycolysis and produce lactate under conditions of oxygen limitation. Lactate efflux from the brain is relatively slow, so prolonged and severe asphyxia may result in a high tissue level of lactate, which has been implicated in neuronal damage.
Authors:
J T Parer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  14     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  376-85     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Institute, University of California, San Francisco 94143.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / embryology*,  metabolism
Cerebrovascular Circulation / physiology
Embryonic and Fetal Development
Female
Fetal Hypoxia / metabolism*
Fetus / metabolism*
Glucose / metabolism
Lactates / metabolism
Lactic Acid
Oxygen Consumption / physiology
Sheep
Chemical
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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