Document Detail


Fetal cells in mother rats contribute to the remodeling of liver and kidney after injury.
MedLine Citation:
PMID:  15541383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal microchimerism indicates a mixture of cells of maternal and fetal origin seen in maternal tissues during and after pregnancy. Controversy exists about whether persistent fetal microchimerism is related with some autoimmune disorders occurring during and after pregnancy. In the current experiment, an animal model in which EGFP positive cells were taken as fetal-origin cells was designed to detect the fetal microchimerism in various maternal organs. Ethanol drinking and gentamicin injection were adopted to induce liver and kidney injury simultaneously. EGFP positive cells were engrafted not only in the maternal circulation and bone marrow, but also in the liver and kidney as hepatocytes and tubular cells, respectively. These results indicate that fetal cells are engrafted to maternal hematopoietic system without apparent injury and they also contribute to the repairing process of maternal liver and kidney.
Authors:
Yu Wang; Hirotsugu Iwatani; Takahito Ito; Naoko Horimoto; Masaya Yamato; Isao Matsui; Enyu Imai; Masatsugu Hori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  325     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2005-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  961-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chimerism / embryology
Ethanol
Female
Fetus / pathology
Gentamicins
Kidney / drug effects,  embryology,  pathology,  physiopathology
Kidney Failure, Chronic / chemically induced,  embryology*,  pathology*,  physiopathology
Liver / drug effects,  embryology,  pathology,  physiopathology
Liver Diseases, Alcoholic / embryology*,  pathology*,  physiopathology
Liver Regeneration
Male
Maternal-Fetal Exchange*
Pregnancy
Rats
Rats, Sprague-Dawley
Regeneration*
Chemical
Reg. No./Substance:
0/Gentamicins; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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