Document Detail


Fetal cells in maternal blood.
MedLine Citation:
PMID:  11260204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal lymphocytes, trophoblasts, and nucleated red blood cells have each been separated from maternal blood by methods such as flow cytometry, magnetic cell sorting, and charge flow separation. The frequency of fetal cells among circulating maternal mononuclear cells remains to be ascertained. Current estimates range from about 10-5 to 10-7, but the numbers may be increased in women carrying aneuploid fetuses. Fetal cells separated from maternal blood have been studied by methods such as polymerase chain reaction and fluorescence in situ hybridization. Among fetal conditions so far identified are sex; human leukocyte antigen and Rh blood types; trisomy 13, 18 and 21; triploidy; and sickle cell anemia and thalassemia. Thus, fetal cell separation might one day be used for screening of the common aneuploidies and, ultimately, for prenatal diagnosis. Individual fetal erythroid precursors have been cultured after separation in some laboratories. Culturing and karyotyping of separated fetal cells might enable diagnosis of a spectrum of chromosomal and genetic disorders. Further development will be required, however, before regular clinical application of these methodologies.
Authors:
S S Wachtel; L P Shulman; D Sammons
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinical genetics     Volume:  59     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-22     Completed Date:  2001-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  74-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Tennessee, 853 Jefferson Avenue, Memphis, TN 38103, USA. swachtel@utmem.edu
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MeSH Terms
Descriptor/Qualifier:
Amniocentesis
Blood Cells / cytology*
Cell Separation
Chromosome Aberrations
Cytodiagnosis / methods
Female
Fetus / cytology*
Humans
Maternal-Fetal Exchange
Polymerase Chain Reaction
Pregnancy
Prenatal Diagnosis*
Trisomy
Trophoblasts / cytology
Grant Support
ID/Acronym/Agency:
HD-32698/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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