Document Detail

Fetal cardiac ventricular volume, cardiac output, and ejection fraction determined with 4-dimensional ultrasound using spatiotemporal image correlation and virtual organ computer-aided analysis.
MedLine Citation:
PMID:  21531373     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to quantify fetal cardiovascular parameters using spatiotemporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL).
STUDY DESIGN: A cross-sectional study was performed in normal pregnancies (19-42 weeks) to evaluate ventricular volume, stroke volume (SV), cardiac output (CO), and ejection fraction (EF). The CO was also expressed as a function of estimated fetal weight and biometric parameters.
RESULTS: The following results were found: (1) 184 STIC datasets; (2) with advancing gestation, ventricular volume, SV, CO, and adjusted CO increased, whereas EF decreased; (3) right ventricular (RV) volume was larger than the left ventricular (LV) volume in systole (0.50 vs 0.27 mL; P < .001) and diastole (1.20 vs 1.03 mL; P < .001); (4) there were no differences between the LV and RV in SV, CO, or adjusted CO; and (5) LV EF was greater than the RV EF (72.2 vs 62.4%; P < .001).
CONCLUSION: Normal fetal cardiovascular physiology is characterized by a larger RV volume and a greater LV EF, resulting in similar LV and RV SV and CO.
Neil Hamill; Lami Yeo; Roberto Romero; Sonia S Hassan; Stephen A Myers; Pooja Mittal; Juan Pedro Kusanovic; Mamtha Balasubramaniam; Tinnakorn Chaiworapongsa; Edi Vaisbuch; Jimmy Espinoza; Francesca Gotsch; Luis F Goncalves; Wesley Lee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2011-04-30
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  205     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-11-17     Completed Date:  2012-01-18     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76.e1-10     Citation Subset:  AIM; IM    
Copyright Information:
Published by Mosby, Inc.
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI, USA.
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MeSH Terms
Cardiac Output / physiology*
Echocardiography, Four-Dimensional / instrumentation,  methods*
Fetal Heart / physiology,  ultrasonography
Gestational Age
Image Processing, Computer-Assisted / instrumentation,  methods*
Organ Size / physiology
Pregnancy Trimester, Second / physiology
Pregnancy Trimester, Third / physiology
Ultrasonography, Prenatal / methods
Ventricular Function / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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