| Fetal cardiac output in the isoimmunized pregnancy: a pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion. | |
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MedLine Citation:
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PMID: 2504042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanism of development of hydrops fetalis in severe isoimmunization has been subject to speculation. We performed pulsed Doppler assessment of cardiac output in 13 severely isoimmunized fetuses before and after intravascular transfusion and compared the results with 37 control fetuses between 20 and 34 weeks' gestation. The cardiac index of the anemic fetuses was significantly greater than that of the control group. A significant (right ventricle, p less than 0.01; left ventricle, p less than 0.02) increase in indexed output was noted from both ventricles and in the combined ventricular output (mean +/- SEM 644 +/- 35.3 ml/kg/min in control fetuses versus 879 +/- 86.0 ml/kg/min in anemic fetuses, p less than 0.006). An increase in cardiac output was also noted when anemic fetuses were compared with gestational age-specific norms. We conclude that severely anemic fetuses of isoimmunized pregnancies tend to have significantly higher cardiac output than do unaffected fetuses and that this high output state may play a part in the development of hydrops fetalis. |
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Authors:
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J A Copel; P A Grannum; J J Green; K Belanger; N Hanna; C C Jaffe; J C Hobbins; C S Kleinman |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 161 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-13 Completed Date: 1989-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 361-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Transfusion, Intrauterine* Cardiac Output* Echocardiography, Doppler* / methods Erythroblastosis, Fetal / diagnosis, physiopathology, therapy Female Fetal Heart / physiopathology* Gestational Age Humans Hydrops Fetalis / diagnosis, physiopathology, therapy Infant, Newborn Pregnancy Pregnancy Complications, Hematologic / diagnosis, physiopathology*, therapy Rh Isoimmunization / diagnosis, physiopathology*, therapy Stroke Volume |
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