| Fetal cardiac defects and increased nuchal translucency thickness: a prospective study. | |
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MedLine Citation:
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PMID: 15507988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to examine prospectively the association between increased nuchal translucency thickness and major cardiac defects in chromosomally normal fetuses. STUDY DESIGN: A prospective cohort study of 263 chromosomally normal fetuses with an increased nuchal translucency thickness at 11 to 14 weeks of gestation at a tertiary referral center was performed. The incidence of major cardiac defects was examined in relation to the fetal nuchal translucency thickness at the 11 to 14 week ultrasound examination. RESULTS: The nuchal translucency thickness measurements ranged from 2.2 to 8.0 mm (median, 3.1 mm). There were 13 cases of major cardiac defects in this cohort, which gave a prevalence of 49.4 of every 1000 fetuses. With the use of the 99th percentile of nuchal translucency thickness, the prevalence rose to 106.7 of every 1000 fetuses. CONCLUSION: In this population of chromosomally normal fetuses with an increased nuchal translucency thickness, the incidence of cardiac defects was high, which suggests that fetal echocardiography is indicated in this group. |
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Authors:
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Fionnuala M McAuliffe; Lisa K Hornberger; Stephanie Winsor; David Chitayat; Karen Chong; Jo-Ann Johnson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 191 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-27 Completed Date: 2004-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1486-90 Citation Subset: AIM; IM |
Affiliation:
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Department of Gynecology and Obstetrics, University Colllege Dublin, National Maternity Hospital, Dublin 7, Ireland. fiannuala.mcauliffe@ucd.ie |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Diseases / ultrasonography* Heart Defects, Congenital / physiopathology, ultrasonography* Humans Nuchal Translucency Measurement* Pregnancy Pregnancy Trimester, First Prospective Studies Ultrasonography, Prenatal* |
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