Document Detail

Fetal cardiac contractility before and after intrauterine transfusion.
MedLine Citation:
PMID:  16254879     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of fetal anemia and intrauterine transfusion on ventricular shortening fraction. METHODS: The end-diastolic and end-systolic transverse dimensions of the left and right ventricles were obtained using M-mode ultrasonography. The shortening fractions of both ventricles were calculated at three time points: before, immediately after and one day after intrauterine transfusion. The blood volume given at intrauterine transfusion was expressed as a percentage of estimated fetoplacental blood volume. RESULTS: Complete measurements were obtained from 49 transfusions in 23 fetuses. Intrauterine transfusion was performed at a median gestational age of 31 (range, 19-35) weeks. Median hemoglobin concentration before and after intrauterine transfusion was 7.9 (range, 2.7-13.7) g/dL and 14.3 (range, 12.7-16.1) g/dL, respectively. Both left and right ventricular shortening fractions differed significantly between the three time points. Left ventricular shortening fraction decreased immediately after transfusion in 43 (88%) of the 49 procedures. Right ventricular shortening fraction decreased immediately after transfusion in 42 (86%) of the 49 procedures. At the first intrauterine transfusion, there was only a weak correlation between the decrease in shortening fraction of both ventricles and the transfused volume (left: R(2) = 0.15; P = 0.20/right: R(2) = 0.005; P = 0.81). CONCLUSION: Transfusion significantly decreases the shortening fraction of both ventricles of the fetal heart. There is, however, little correlation between the decrease in shortening fraction and the volume of red cells given at intrauterine transfusion. Published by John Wiley & Sons, Ltd.
E Sikkel; F J C M Klumper; D Oepkes; A K K Teunissen; R H Meerman; S Le Cessie; H H H Kanhai; F P H A Vandenbussche
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  26     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2006-02-09     Revised Date:  2009-07-23    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 ISUOG.
Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Anemia / physiopathology*,  therapy
Blood Transfusion, Intrauterine*
Blood Volume / physiology
Erythrocyte Count
Fetal Diseases / physiopathology*,  therapy
Fetal Heart / physiology*,  ultrasonography
Gestational Age
Heart Ventricles / embryology,  ultrasonography
Myocardial Contraction / physiology
Ultrasonography, Prenatal / methods*
Ventricular Function / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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