| Fetal cardiac arrhythmia detection and in utero therapy. | |
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MedLine Citation:
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PMID: 20418904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human fetal heart develops arrhythmias and conduction disturbances in response to ischemia, inflammation, electrolyte disturbances, altered load states, structural defects, inherited genetic conditions, and many other causes. Yet sinus rhythm is present without altered rate or rhythm in some of the most serious electrophysiological diseases, which makes detection of diseases of the fetal conduction system challenging in the absence of magnetocardiographic or electrocardiographic recording techniques. Life-threatening changes in QRS or QT intervals can be completely unrecognized if heart rate is the only feature to be altered. For many fetal arrhythmias, echocardiography alone can assess important clinical parameters for diagnosis. Appropriate treatment of the fetus requires awareness of arrhythmia characteristics, mechanisms, and potential associations. Criteria to define fetal bradycardia specific to gestational age are now available and may allow detection of ion channelopathies, which are associated with fetal and neonatal bradycardia. Ectopic beats, once thought to be entirely benign, are now recognized to have important pathologic associations. Fetal tachyarrhythmias can now be defined precisely for mechanism-specific therapy and for subsequent monitoring of response. This article reviews the current and future diagnostic techniques and pharmacologic treatments for fetal arrhythmia. |
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Authors:
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Janette F Strasburger; Ronald T Wakai |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Cardiology Volume: 7 ISSN: 1759-5010 ISO Abbreviation: Nat Rev Cardiol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-27 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101500075 Medline TA: Nat Rev Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 277-90 Citation Subset: IM |
Affiliation:
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Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, USA. jstrasbu@mcw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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diagnosis*,
mortality,
therapy* Atrioventricular Block / diagnosis, mortality, therapy Bradycardia / diagnosis, mortality, therapy Echocardiography, Doppler / methods Electrocardiography / methods Female Fetal Diseases / diagnosis*, mortality, therapy* Fetal Heart / abnormalities, physiopathology, ultrasonography Fetal Monitoring / methods Follow-Up Studies Gestational Age Heart Conduction System / abnormalities, physiopathology Humans Pregnancy Prenatal Diagnosis / methods* Risk Assessment Survival Rate Ultrasonography, Prenatal / methods |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL063174-09A1/HL/NHLBI NIH HHS; R01 HL063174-10/HL/NHLBI NIH HHS; R01 HL063174-11/HL/NHLBI NIH HHS; R01 HL063174-12/HL/NHLBI NIH HHS; R01HL63174/HL/NHLBI NIH HHS; R21 HD049022-01A1/HD/NICHD NIH HHS; R21 HD049022-02/HD/NICHD NIH HHS; R21HD049022/HD/NICHD NIH HHS; R42HL092755/HL/NHLBI NIH HHS; R43HD055091/HD/NICHD NIH HHS; R44HL082017/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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