Document Detail

Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study.
MedLine Citation:
PMID:  20505549     Owner:  NLM     Status:  MEDLINE    
We assessed the effects of a single episode of maternal alcohol intoxication on fetal brain blood perfusion in three pregnant dams (baboons) at the 24th week of pregnancy using dynamic susceptibility contrast magnetic resonance imaging. After the oral administration of alcohol, there was a four-fold increase in the peak contrast concentrations in the fetal brain. In addition, we observed a two- to three-fold increase in the contrast uptake and washout rates in the fetal brain. The underlying mechanisms of these changes are unknown, but we hypothesized that these could include the alcohol-mediated changes in placental permeability and fetal cerebral blood flow. Our findings indicate that alcohol intoxication produces profound changes, which may detrimentally influence neurodevelopmental processes in the brain.
Peter Kochunov; Carlos Castro; Duff M Davis; Donald Dudley; Hsiao-Ying Wey; David Purdy; Peter T Fox; Calvin Simerly; Gerald Schatten
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neuroreport     Volume:  21     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-17     Completed Date:  2010-10-18     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  716-21     Citation Subset:  IM    
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MeSH Terms
Alcoholic Intoxication / physiopathology
Brain / drug effects*,  embryology*,  physiopathology
Central Nervous System Depressants / blood,  poisoning*
Cerebrovascular Circulation
Contrast Media / pharmacokinetics
Ethanol / blood,  poisoning*
Gadolinium DTPA / pharmacokinetics
Magnetic Resonance Imaging / methods
Myometrium / drug effects,  physiopathology
Papio hamadryas
Perfusion Imaging / methods
Time Factors
Uterus / drug effects,  physiopathology
Grant Support
#1R01AG029412-01/AG/NIA NIH HHS; #P01 HD047675/HD/NICHD NIH HHS; #P51-RR013986/RR/NCRR NIH HHS; K01 EB006395/EB/NIBIB NIH HHS; K01 EB006395-05/EB/NIBIB NIH HHS; K01#EB006395/EB/NIBIB NIH HHS; R24 RR013632/RR/NCRR NIH HHS
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Contrast Media; 122795-43-1/gadodiamide; 3K9958V90M/Ethanol; K2I13DR72L/Gadolinium DTPA

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