| Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study. | |
| | |
MedLine Citation:
|
PMID: 20505549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We assessed the effects of a single episode of maternal alcohol intoxication on fetal brain blood perfusion in three pregnant dams (baboons) at the 24th week of pregnancy using dynamic susceptibility contrast magnetic resonance imaging. After the oral administration of alcohol, there was a four-fold increase in the peak contrast concentrations in the fetal brain. In addition, we observed a two- to three-fold increase in the contrast uptake and washout rates in the fetal brain. The underlying mechanisms of these changes are unknown, but we hypothesized that these could include the alcohol-mediated changes in placental permeability and fetal cerebral blood flow. Our findings indicate that alcohol intoxication produces profound changes, which may detrimentally influence neurodevelopmental processes in the brain. |
| | |
Authors:
|
Peter Kochunov; Carlos Castro; Duff M Davis; Donald Dudley; Hsiao-Ying Wey; David Purdy; Peter T Fox; Calvin Simerly; Gerald Schatten |
Related Documents
:
|
15541849 - Symmetrical fetal growth retardation after gestational cocaine exposure in the rat. 795609 - Local treatment of psoriasis of the scalp with clobetasol propionate and betamethasone-... 8638459 - The hazards of reproduction in space. 8921459 - The repeatability of self-reported exposure after miscarriage. alspac study team. avon ... 15380829 - Cocaine-induced inhibition of process outgrowth in locus coeruleus neurons: role of ges... 18000129 - Systematic review of the fetal effects of prenatal binge-drinking. 156579 - Guidelines to birth control counselling of the physically handicapped. 21668769 - Aerobic vaginitis in pregnancy. 18256329 - Abortion in mice with excessive erythrocytosis is due to impaired arteriogenesis of the... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Neuroreport Volume: 21 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-17 Completed Date: 2010-10-18 Revised Date: 2011-08-01 |
Medline Journal Info:
|
Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
|
Languages: eng Pagination: 716-21 Citation Subset: IM |
Affiliation:
|
Research Imaging Institute, The University of Texas Health Science Center at San Antonio, Texas 78229, USA. kochunov@uthscsa.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcoholic Intoxication
/
physiopathology Animals Brain / drug effects*, embryology*, physiopathology Central Nervous System Depressants / blood, poisoning* Cerebrovascular Circulation Contrast Media / pharmacokinetics Ethanol / blood, poisoning* Female Gadolinium DTPA / pharmacokinetics Magnetic Resonance Imaging / methods Myometrium / drug effects, physiopathology Papio hamadryas Perfusion Imaging / methods Pregnancy Time Factors Uterus / drug effects, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
|
#1R01AG029412-01/AG/NIA NIH HHS; #P01 HD047675/HD/NICHD NIH HHS; #P51-RR013986/RR/NCRR NIH HHS; K01 EB006395-05/EB/NIBIB NIH HHS; K01#EB006395/EB/NIBIB NIH HHS; R24 RR013632/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Depressants; 0/Contrast Media; 122795-43-1/gadodiamide; 64-17-5/Ethanol; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nitric oxide synthase inhibition attenuates cutaneous vasodilation during postmenopausal hot flash e...
Next Document: An ignoring task improves validity of cortical evoked response audiometry.