Document Detail


Fetal body volume: use at MR imaging to quantify relative lung volume in fetuses suspected of having pulmonary hypoplasia.
MedLine Citation:
PMID:  17053198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To retrospectively determine an algorithm based on fetal body volume (FBV) by using magnetic resonance (MR) imaging to calculate relative lung volume in fetuses with normally developed lungs and prospectively assess the use of this algorithm in predicting pulmonary hypoplasia in the late second and early third trimesters for fetuses at risk for pulmonary hypoplasia. MATERIALS AND METHODS: Oral informed consent was obtained for the prospective component of this ethics committee-approved study. MR imaging lung volumetry was performed in 36 fetuses with normally developed lungs between 18 and 39 weeks gestational age by using T2-weighted single-shot fast spin-echo imaging in fetal transverse and sagittal planes. Findings were then correlated with biometric variables and gestational age. The best-performing algorithm was applied to 37 fetuses (between 18 and 29 weeks gestational age) at risk for pulmonary hypoplasia to determine observed-expected lung volume ratio. This group was stratified according to pregnancy management, and observed-expected ratios were correlated with outcome. In fetuses with isolated congenital diaphragmatic hernia (CDH) (n = 19), observed-expected ratio was correlated with lung-head ratio, neonatal survival in pregnancies managed expectantly (n = 13), and/or lung-body weight ratio at necropsy (n = 9). For that purpose, linear regression correlation was used with the Pearson correlation coefficient; P < .05 was considered to indicate a significant difference. RESULTS: Total fetal lung volume correlated best with total FBV (r = 0.96, P < .05). Observed-expected ratio based on FBV correlated with lung-head ratio in patients with CDH (r = 0.71, P < .001) and with lung-body weight ratio at necropsy (r = 0.68, P < .05) and could be used to help predict neonatal survival. CONCLUSION: FBV measured with MR imaging can be used as a single parameter in an algorithm and showed closest correlation with normal total fetal lung volume. In the transition from second to third trimester, this algorithm enabled calculation of the observed-expected ratio and prediction of outcome in fetuses at risk for pulmonary hypoplasia.
Authors:
Mieke Cannie; Jacques C Jani; Frederik De Keyzer; Roland Devlieger; Dominique Van Schoubroeck; Ingrid Witters; Guy Marchal; Steven Dymarkowski; Jan A Deprest
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Publication Detail:
Type:  Journal Article     Date:  2006-10-19
Journal Detail:
Title:  Radiology     Volume:  241     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-01-05     Revised Date:  2007-11-26    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  847-53     Citation Subset:  AIM; IM    
Copyright Information:
(c) RSNA, 2006.
Affiliation:
Department of Radiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Female
Fetal Organ Maturity
Humans
Lung / abnormalities,  embryology*
Lung Volume Measurements / methods*
Magnetic Resonance Imaging / methods*
Predictive Value of Tests
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prenatal Diagnosis / methods
Prospective Studies
Retrospective Studies
Comments/Corrections
Comment In:
Radiology. 2007 Nov;245(2):608-9; author reply 609   [PMID:  17940315 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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