Document Detail

Fetal blood sampling immediately before and within 24 hours of death in monochorionic twin pregnancies complicated by single intrauterine death.
MedLine Citation:
PMID:  9757993     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our goal was to investigate the mechanisms that play a role in intrauterine death in monochorionic twins and that contribute to the high perinatal mortality and morbidity in the survivors. STUDY DESIGN: In 8 monochorionic twin pregnancies complicated by the intrauterine death of a single twin, we took samples from 5 twin fetuses immediately before death and from 4 of their cotwins and also from 4 surviving fetuses within 24 hours after death of the cotwin. RESULTS: Four of the 5 fetuses sampled who subsequently died were acidemic and 3 were hypoxemic. None of these fetuses or their cotwins were anemic at that time. All 4 survivors sampled within 24 hours of the death of each cotwin had low hematocrits. CONCLUSION: Fetal anemia, probably the consequence of acute blood loss just before the time of death of the cotwin, may play a role in the high mortality and morbidity found in the surviving twin. It is unlikely that immediate delivery of the surviving twin after death could affect the outcome.
U Nicolini; M P Pisoni; E Cela; A Roberts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  179     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  800-3     Citation Subset:  AIM; IM    
1st Department of Obstetrics and Gynecology, University of Milano, Clinica Mangiagalli, Milan, Italy.
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MeSH Terms
Acid-Base Equilibrium
Blood Specimen Collection*
Chorion / anatomy & histology*
Fetal Blood* / chemistry
Fetal Death / blood*,  ultrasonography
Pregnancy Outcome
Pregnancy, Multiple*
Time Factors
Ultrasonography, Prenatal
Comment In:
Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):507-8   [PMID:  9988835 ]

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