| Fetal autonomic response to severe acidaemia during labour. | |
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MedLine Citation:
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PMID: 20025619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Spectral analysis of heart-rate variability is used to monitor autonomic nervous system fluctuations. The low-frequency component is associated with sympathetic and parasympathetic modulation and the high-frequency component is associated with parasympathetic modulation. The objective was to study whether changes in low-frequency or high-frequency power of heart-rate variability occur in case of fetal distress. DESIGN: Case-control study. SETTING: Obstetric unit of a tertiary-care teaching hospital. POPULATION: Twenty healthy human fetuses during labour at term of which ten had an umbilical artery pH < 7.05 (cases), and ten had an arterial pH > 7.20 (controls) after birth. METHODS: Spectral information about fetal beat-to-beat heart rate, calculated from direct fetal electrocardiogram registrations, was obtained by using a short-time Fourier transform. MAIN OUTCOME MEASURES: Absolute power and normalised power in the low-frequency and high-frequency bands. RESULTS: No differences were found between fetuses with and without acidaemia in absolute low or high frequency power (P = 0.2 and P = 0.3, respectively). During the last 30 minutes of labour, acidaemic fetuses had significantly increased normalised low-frequency power (P = 0.01) and decreased normalised high-frequency power (P = 0.03) compared with non-acidaemic fetuses. These differences were not observed from 3 to 2 hours before birth (P = 0.7 and P = 0.9, respectively). CONCLUSION: The autonomic nervous system of human fetuses at term responds adequately to severe stress during labour. Normalised low and high frequency power of heart-rate variability might be able to discriminate between normal and abnormal fetal condition. |
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Authors:
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J O E H van Laar; C H L Peters; R Vullings; S Houterman; J W M Bergmans; S G Oei |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2009-12-17 |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 117 ISSN: 1471-0528 ISO Abbreviation: BJOG Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 429-37 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynaecology, M?xima Medical Centre, Veldhoven. joehvanlaar@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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physiopathology* Autonomic Nervous System / embryology* Case-Control Studies Delivery, Obstetric Fetal Distress / diagnosis*, physiopathology Fetal Monitoring / methods, standards Gestational Age Heart Rate, Fetal / physiology* Humans Hydrogen-Ion Concentration Stress, Physiological / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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