| Fetal antigen 1 (FA1) in the human pancreas: cell type expression, topological and quantitative variations during development. | |
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MedLine Citation:
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PMID: 8512086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monospecific rabbit anti-human fetal antigen 1 (FA1), was used to examine the distribution of FA1 during the development of the human fetal pancreas and liver using an indirect immunoperoxidase technique. FA1 was expressed by 94% of the glandular epithelial cells of the branching ducts in the pancreatic anlage at week 7 of gestation. This pattern changed during the development of the human pancreas, 64% of the glandular cells being FA1 positive at week 17 of gestation, decreasing to 11% in the infant (4 months after birth). In the infant and adults the FA1 expression was restricted to a subpopulation of beta-cells within the islets of Langerhans. Insulin immunoreactive cells were scattered throughout the epithelium of primitive branching pancreatic ducts at week 7 of gestation, well before the formation of islets. From the 7th through to the 17th week of gestation, FA1 was found in the cytoplasm of fetal hepatocytes, whereas no staining was observed in the liver from a 4-month-old infant. No FA1 expression was found in the epithelium of the developing gut. The present findings indicate that the glandular epithelial cells in the developing pancreas may serve as stem cells, which, if appropriately induced, may differentiate into endocrine cells. Fetal antigen 1 (FA1) may take part in or be a result of this differentiation. |
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Authors:
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D Tornehave; P Jansen; B Teisner; H B Rasmussen; J Chemnitz; G Moscoso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anatomy and embryology Volume: 187 ISSN: 0340-2061 ISO Abbreviation: Anat. Embryol. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-07-15 Completed Date: 1993-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505194 Medline TA: Anat Embryol (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 335-41 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cytology, Odense University, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Fetal Proteins / analysis* Humans Infant Insulin / analysis* Liver / embryology*, growth & development, immunology Pancreas / chemistry, embryology*, growth & development, immunology |
| Chemical | |
Reg. No./Substance:
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0/Fetal Proteins; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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