Document Detail

Fetal anemia leads to augmented contractile response to hypoxic stress in adulthood.
MedLine Citation:
PMID:  12775557     Owner:  NLM     Status:  MEDLINE    
In response to chronic fetal anemia, coronary blood flow, maximal coronary conductance, and coronary reserve increase. We sought to determine whether chronic fetal anemia alters left ventricular (LV) function in adulthood. We studied adult sheep that had been made anemic for 20 days in utero by phlebotomy. They were transfused just before birth. At 7 mo of age, LV function was measured by pressure-volume loops at rest and during hypoxic stress. The in utero anemia group (n = 8) did not differ from controls (n = 5) with respect to hematocrit, heart and body weight, or baseline hemodynamic parameters. However, the effect of hypoxia (relative to baseline) on multiple indexes of systolic function was different between the two groups. End-systolic elastance increased in the in utero anemia group (baseline to hypoxia) by 4.15 +/- 3.47 mmHg/ml (mean +/- SD) but changed little in controls (0.24 +/- 0.45), which shows that the response to hypoxia was significantly different (P < 0.01) between groups. Similarly, the maximum derivative of LV pressure with respect to time increased in the in utero anemia group (486 +/- 340 mmHg/s,) but on average fell in the controls (-503 +/- 211 mmHg/s) with the response again being significantly different (P < 0.03). We conclude that in sheep, perinatal anemia can alter cardiac responses to hypoxic stress in the adult long after restoration of normocythemia.
Craig S Broberg; George D Giraud; Jess M Schultz; Kent L Thornburg; A Roger Hohimer; Lowell E Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-05-29
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  285     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-11     Completed Date:  2003-09-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R649-55     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Medical Research Bldg., L-458, 3181 SW Sam Jackson Park Rd., Portland, OR 97201-3098, USA.
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MeSH Terms
Acute Disease
Age Factors
Anemia / physiopathology*
Anoxia / physiopathology*
Arterioles / physiology
Coronary Circulation / physiology
Fetal Diseases / physiopathology*
Stress, Physiological / physiopathology
Systole / physiology
Ventricular Function, Left / physiology*
Grant Support
LH-45043//PHS HHS; P02 HD-34430/HD/NICHD NIH HHS
Comment In:
Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R517-8   [PMID:  12909577 ]

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