Document Detail


Fetal anaemia as a cause of fetal injury: diagnosis and management.
MedLine Citation:
PMID:  16601468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: This review provides up-to-date information on the diagnosis and management of fetal anaemia. RECENT FINDINGS: Exciting advances in the field of red blood cell isoimmunization are phasing out the need for invasive procedures. Rhesus blood group genotyping using fetal DNA in maternal plasma has been introduced into clinical practice with remarkable success. The role of middle cerebral artery peak systolic velocity in screening for fetal anaemia has been confirmed in various causes of fetal anaemia. A recent review of a successful Iran national screening programme for thalassaemia provided a timely and valuable educational opportunity. The value of intrauterine transfusion as a treatment for fetal anaemia was demonstrated by both high success rate and low procedure-related pregnancy loss rate. SUMMARY: Fetal anaemia is one of the severe fetal conditions that affect the worldwide population. Rhesus isoimmunization remains an important health issue despite the recommendation for anti-D immunoglobulin prophylaxis and injection after sensitizing events. Noninvasive ultrasound diagnostic methods have replaced traditional invasive procedures in the assessment of fetus at risk of anaemia due to various causes, including red blood cell isoimmunization, parvovirus B19 infection and thalassaemia. The increased availability of intrauterine transfusion will help to improve the prognosis of these anaemic fetuses.
Authors:
Lin Wai Chan; Tze Kin Lau; Tony Kwok Hung Chung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  18     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-07     Completed Date:  2008-06-20     Revised Date:  2008-10-07    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  100-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR. danielchan@cuhk.edu.hk
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MeSH Terms
Descriptor/Qualifier:
Blood Transfusion, Intrauterine
Erythroblastosis, Fetal / diagnosis*,  therapy*
Female
Humans
Parvoviridae Infections / blood,  complications
Parvovirus B19, Human / pathogenicity
Pregnancy
Rh-Hr Blood-Group System / immunology
Thalassemia / diagnosis,  therapy
Ultrasonography, Prenatal
Chemical
Reg. No./Substance:
0/Rh-Hr Blood-Group System

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