Document Detail


Fetal alcohol syndrome: new perspectives for an ancient and underestimated problem.
MedLine Citation:
PMID:  21942588     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The knowledge of the dangers of alcohol consumption during pregnancy isn't indeed a new issue, but the recent evidences of ethyl-glucuronide and ethyl-sulfate in meconium as novel biomarkers of prenatal ethanol exposure open new perspectives for the early diagnosis of the alcohol-related birth defects. This is crucial for a better developmental outcome of the affected patients and for preventing additional cases in at risk families. The fetal alcohol syndrome is not a single entity but represents the most severe form of a spectrum of disorders, including distinctive craniofacial alterations, stunted growth and behavioral abnormalities, caused by complex gene-environment interactions. FAS must always be a diagnosis of exclusion and have to be differentiated from many conditions caused by other embryotoxin agents and genetic syndromes that share some phenotypic features. Even if the first trimester is considered the most vulnerable period, nowadays is known that a fetal damage might occur throughout all gestation. Since ethanol consumption is constantly increasing among young women, a substantial amount of work has to be made to implement the knowledge on alcohol fetal effects among women of childbearing age; moreover, awareness and training among professionals in the health care system might play a critical role in the early diagnosis of these serious conditions.
Authors:
Luisa de Sanctis; Luigi Memo; Simona Pichini; Luigi Tarani; Federica Vagnarelli
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  24     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  34-37     Citation Subset:  -    
Affiliation:
Department of Pediatric Sciences, University of Torino , Italy.
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