| Fetal alcohol syndrome: inhibition of placental zinc transport as a potential mechanism for fetal growth retardation in the rat. | |
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MedLine Citation:
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PMID: 7086268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Growth retardation is one of the principal features of fetal alcohol syndrome. The cause of this growth retardation is unknown. Because of the clinical similarities between fetal alcohol syndrome and prenatal zinc deficiency, we studied in vivo the effect of short-term and long-term ethanol ingestion during pregnancy on placental transport of zinc in pair-fed rats. Our results indicate that both short- and long-term ethanol depressed zinc-65 uptake in the placenta and fetus by 40% and 30%, respectively, compared to pair-fed controls (p less than 0.05). Total zinc concentration in fetuses of the long-term ethanol group was significantly decreased compared to pair-fed controls (p less than 0.05). Although the mechanism of action of ethanol in producing the fetal alcohol syndrome maybe multiple, our findings suggest that a decrease in the availability of zinc to the fetus may represent one of the contributory factors in the growth retardation of fetal alcohol syndrome. |
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Authors:
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F K Ghishan; R Patwardhan; H L Greene |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 100 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-08-07 Completed Date: 1982-08-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 45-52 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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physiology* Animals Depression, Chemical Diet Female Fetal Alcohol Syndrome / metabolism* Fetal Growth Retardation / etiology* Maternal-Fetal Exchange Organ Size / drug effects Placenta / metabolism* Pregnancy Rats Rats, Inbred Strains Zinc / analysis, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AM 26657-02/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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