| Fetal alcohol spectrum disorders in young adulthood. | |
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MedLine Citation:
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PMID: 17236896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis that fetal alcohol syndrome (FAS), with the full phenotype, and fetal alcohol effect (FAE), with some but not all of the features, can be combined under the umbrella term fetal alcohol spectrum disorders (FASD). STUDY DESIGN: We investigated the long-term sequelae of intrauterine alcohol exposure using physical examination, psychosocial interviews, and a behavioral checklist in a 20-year follow-up study of 37 patients with FASD originally diagnosed as having FAS or FAE in infancy and childhood. RESULTS: Although the characteristic craniofacial malformations of FAS/FAE diminish over time, microcephaly, a poorly developed philtrum and a thin upper lip, and, to a lesser degree, short stature and underweight (in boys) persist. In females, adult body weight increases. Persistent mental handicaps, including intellectual disability, limited occupational options, and dependent living, are the major sequelae, and the scores for various behavioral problems are significantly increased. CONCLUSIONS: The devastating effects of intrauterine exposure to alcohol persist into early adulthood and severely limit careers and independent living. |
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Authors:
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Hans-Ludwig Spohr; Judith Willms; Hans-Christoph Steinhausen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 150 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-22 Completed Date: 2007-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 175-9, 179.e1 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Hospital of the German Red Cross, Berlin, Germany. h.spohr@drk-kliniken-westend.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Distribution Body Mass Index Child Cohort Studies Developmental Disabilities / diagnosis*, epidemiology* Female Fetal Alcohol Syndrome / diagnosis*, epidemiology* Humans Incidence Male Pregnancy Prenatal Exposure Delayed Effects Probability Prognosis Risk Assessment Severity of Illness Index Sex Distribution |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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