Document Detail


Fetal adrenal gland volume: a novel method to identify women at risk for impending preterm birth.
MedLine Citation:
PMID:  17400846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the risk of preterm birth (delivery at less than 37 weeks of gestation) by evaluating the fetal adrenal gland volume, hallmark of activation of the fetal hypothalamic-pituitary-adrenal axis, measured by 3-dimensional ultrasonography.
METHODS: We performed 3-dimensional ultrasound examination of the fetal adrenal gland volume in 126 singleton fetuses, prospectively comparing those born to mothers with signs or symptoms of preterm labor (n=53) to control subjects (n=73). Multiplanar technique with rotational methods for measurement of fetal adrenal gland volume was performed by using Virtual Organ Computer-Aided Analysis (VOCAL) technology.
RESULTS: The fetal adrenal gland volume was successfully examined in 86.5% of the cases. There was a direct relationship between the fetal adrenal gland volume and estimated fetal weight. A corrected adrenal gland volume of greater than 422 mm3/kg was best in predicting preterm birth within 5 days from the time of the measurement. The sensitivity, specificity, and positive and negative likelihood ratios were 92%, 99%, 93.5, and 0.08, respectively. Multiple logistic regression analysis showed that the corrected adrenal gland volume was the only significant independent predictor factor of preterm birth within 5 days of measurement.
CONCLUSION: Corrected adrenal gland volume measurement may identify women at risk for impending preterm birth. This information can be generated noninvasively and in time for clinical decision making.
LEVEL OF EVIDENCE: II.
Authors:
Ozhan M Turan; Sifa Turan; Edmund F Funai; Irina A Buhimschi; Joshua A Copel; Catalin S Buhimschi
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  109     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-04-26     Revised Date:  2013-04-08    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  855-62     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA. sifa_ozhan@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / anatomy & histology*,  ultrasonography
Adult
Female
Fetal Development / physiology*
Gestational Age*
Humans
Image Processing, Computer-Assisted
Organ Size
Predictive Value of Tests
Pregnancy
Premature Birth / ultrasonography*
Prospective Studies
Risk Assessment
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
R01 HD 047321/HD/NICHD NIH HHS; R01 HD047321/HD/NICHD NIH HHS; R01 HD047321-01/HD/NICHD NIH HHS; R01 HD047321-02/HD/NICHD NIH HHS; R01 HD047321-03/HD/NICHD NIH HHS
Comments/Corrections
Comment In:
Obstet Gynecol. 2007 Jul;110(1):187; author reply 187-8   [PMID:  17601919 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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