Document Detail

Fetal adiponectin and resistin in correlation with birth weight difference in monozygotic twins with discordant growth.
MedLine Citation:
PMID:  18059079     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Various studies have demonstrated an increased risk for adult diseases in newborns born small-for-gestational-age (SGA). Adiponectin and resistin can be detected in cord blood and are suggested to affect insulin resistance (IR). This might represent a link between metabolic syndrome and SGA birth.
STUDY DESIGN: We investigated the relationship between the adipocytokines and inter-twin birth weight (BW) difference of 31 monozygotic twins with twin-twin transfusion syndrome; in 14 twin pairs BW difference was >15% (1 SGA twin, 1 appropriate-for-gestational-age, AGA, twin).
RESULTS: BW and length of all patients were positively related to adiponectin (r = 0.57; p < 0.0001; r = 0.47; p < 0.0001) and to resistin (r = 0.31; p < 0.01; r = 0.35; p < 0.01). In 71% (10/14), the SGA twins showed lower adiponectin concentrations than their AGA co-twins (only 6/14 for resistin). To correct for gestational age we calculated the relationship between the intrapair differences (Delta) of BW and Delta of the hormones. We found Delta BW positively correlated with adiponectin (r = 0.55; p < 0.001) but not with resistin (r = 0.22; p = 0.2). Delta adiponectin was positively correlated with Delta resistin (r = 0.45; p < 0.01).
CONCLUSION: These data demonstrate that adiponectin and resistin levels are associated with BW with only adiponectin levels being reduced in SGA children independently of gestational age. Prenatally different metabolic status between the twins might predispose the SGA twin to develop IR later in life.
Bettina C Gohlke; Peter Bartmann; Rolf Fimmers; Agnes Huber; Kurt Hecher; Christian L Roth
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Publication Detail:
Type:  Journal Article; Twin Study     Date:  2006-09-25
Journal Detail:
Title:  Hormone research     Volume:  69     ISSN:  1423-0046     ISO Abbreviation:  Horm. Res.     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-01-10     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  37-44     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Department of Paediatrics, University of Bonn, Bonn, Germany.
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MeSH Terms
Adiponectin / blood
Birth Weight
Fetofetal Transfusion / blood*,  genetics
Growth Disorders / blood*,  genetics
Infant, Newborn
Infant, Small for Gestational Age / blood
Resistin / blood*
Twins, Monozygotic / blood*
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/RETN protein, human; 0/Resistin

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