| Fetal abnormalities leading to termination of singleton pregnancy: the 7-year experience of a single medical center. | |
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MedLine Citation:
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PMID: 16874842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the distribution of fetal indications leading to termination of pregnancy (TOP) in our institute. METHODS: All pregnant women with singleton pregnancies who underwent TOP due to fetal abnormalities in our institute between January, 1998 and December, 2004 were divided between early TOP (<23 weeks' gestation) and late TOP (> or =23 weeks' gestation). RESULTS: There were 328 (71%) and 134 (29%) early and late TOPs, respectively. The TOPs were performed at a mean gestational age of 20.1 +/- 4.8 weeks. The groups varied significantly in the indications for TOP (p = 0.04), which were primarily structural abnormalities (mostly CNS) followed by chromosomal/genetic defects. Fetal structural abnormalities were more common in the late TOP group (62.7% vs 54.2%) while chromosomal-genetic defects were more common in the early TOP group (40% vs 29.1%, respectively). Fetal infection (mostly cytomegalovirus) was similar ( approximately 4%) for both groups. The early TOP group had significantly more hydrops, gastrointestinal, face and neck abnormalities, while the late TOP group had significantly more cardiovascular abnormalities (p < 0.01). CONCLUSIONS: The impact of early chromosomal/genetic screening contributes to early TOPs, while midgestation anomaly and cardiac scanning significantly contribute to late TOPs. Fetal infection contributes equally to both categories of TOPs. |
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Authors:
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Zvi Vaknin; Ido Ben-Ami; Orit Reish; Arie Herman; Ron Maymon |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 26 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-16 Completed Date: 2007-02-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 938-43 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Eugenic
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statistics & numerical data* Adolescent Adult Central Nervous System / abnormalities Chromosome Aberrations Chromosome Disorders / diagnosis Congenital Abnormalities / epidemiology* Female Gestational Age Humans Middle Aged Pregnancy Prenatal Diagnosis* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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