Document Detail

Fetal abnormalities leading to termination of singleton pregnancy: the 7-year experience of a single medical center.
MedLine Citation:
PMID:  16874842     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the distribution of fetal indications leading to termination of pregnancy (TOP) in our institute. METHODS: All pregnant women with singleton pregnancies who underwent TOP due to fetal abnormalities in our institute between January, 1998 and December, 2004 were divided between early TOP (<23 weeks' gestation) and late TOP (> or =23 weeks' gestation). RESULTS: There were 328 (71%) and 134 (29%) early and late TOPs, respectively. The TOPs were performed at a mean gestational age of 20.1 +/- 4.8 weeks. The groups varied significantly in the indications for TOP (p = 0.04), which were primarily structural abnormalities (mostly CNS) followed by chromosomal/genetic defects. Fetal structural abnormalities were more common in the late TOP group (62.7% vs 54.2%) while chromosomal-genetic defects were more common in the early TOP group (40% vs 29.1%, respectively). Fetal infection (mostly cytomegalovirus) was similar ( approximately 4%) for both groups. The early TOP group had significantly more hydrops, gastrointestinal, face and neck abnormalities, while the late TOP group had significantly more cardiovascular abnormalities (p < 0.01). CONCLUSIONS: The impact of early chromosomal/genetic screening contributes to early TOPs, while midgestation anomaly and cardiac scanning significantly contribute to late TOPs. Fetal infection contributes equally to both categories of TOPs.
Zvi Vaknin; Ido Ben-Ami; Orit Reish; Arie Herman; Ron Maymon
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  26     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-16     Completed Date:  2007-02-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  938-43     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel.
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MeSH Terms
Abortion, Eugenic / statistics & numerical data*
Central Nervous System / abnormalities
Chromosome Aberrations
Chromosome Disorders / diagnosis
Congenital Abnormalities / epidemiology*
Gestational Age
Middle Aged
Prenatal Diagnosis*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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