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Fetal Loss and Hyposulfataemia in Pregnant NaS1 Transporter Null Mice.
MedLine Citation:
PMID:  21403420     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Sulfate is important for growth and development, and is supplied from mother to fetus throughout pregnancy. We used NaS1 sulfate transporter null (Nas1-/-) mice to investigate the role of NaS1 in maintaining sulfate homeostasis during pregnancy and to determine the physiological consequences of maternal hyposulfataemia on fetal, placental and postnatal growth. We show that maternal serum (≤0.5 mM), fetal serum (<0.1 mM) and amniotic fluid (≤0.5 mM) sulfate levels were significantly lower in pregnant Nas1-/- mice when compared with maternal serum (≍2.0 mM), fetal serum (≍1.5 mM) and amniotic fluid (≍1.7 mM) sulfate levels in pregnant Nas1+/+ mice. After 12 days of pregnancy, fetal reabsorptions led to markedly reduced (by ≥50%) fetal numbers in Nas1-/- mice. Placental labyrinth and spongiotrophoblast layers were increased (by ≍140%) in pregnant Nas1-/- mice when compared to pregnant Nas1+/+ mice. Birth weights of progeny from female Nas1-/- mice were increased (by ≍7%) when compared to progeny of Nas1+/+ mice. These findings show that NaS1 is essential to maintain high maternal and fetal sulfate levels, which is important for maintaining pregnancy, placental development and normal birth weight.
Authors:
Paul Anthony Dawson; Pearl Sim; David Gordon Simmons; Daniel Markovich
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-8
Journal Detail:
Title:  The Journal of reproduction and development     Volume:  -     ISSN:  1348-4400     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438792     Medline TA:  J Reprod Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Biomedical Sciences, University of Queensland.
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