Document Detail


Fetal Leydig cells: progenitor cell maintenance and differentiation.
MedLine Citation:
PMID:  19875489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In most eutherian mammals, sexually dimorphic masculinization is established by androgen-producing fetal Leydig cells in the embryonic testis. Fetal Leydig cells, which lack expression of the testis-determining gene SRY, arise after the appearance of SRY-expressing Sertoli cells. Therefore, the appearance and differentiation of fetal Leydig cells are probably regulated by factors derived from Sertoli cells. Results from mouse genetic models have revealed that maintenance and differentiation of fetal Leydig cell population depends upon a balance between differentiation-promoting and differentiation-suppressing mechanisms. Although paracrine signaling via Sertoli cell-derived Hedgehog ligands is necessary and sufficient for fetal Leydig cell formation, cell-cell interaction via Notch signaling and intracellular transcription factors such as POD1 are implicated as suppressors of fetal Leydig cell differentiation. This review provides a model that summarizes the recent findings in fetal Leydig cell development.
Authors:
Ivraym B Barsoum; Humphrey H-C Yao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-10-29
Journal Detail:
Title:  Journal of andrology     Volume:  31     ISSN:  1939-4640     ISO Abbreviation:  J. Androl.     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-06-14     Revised Date:  2012-09-24    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-5     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61802, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation*
Fetal Stem Cells / physiology
Leydig Cells / cytology*,  physiology
Male
Mice
Signal Transduction
Grant Support
ID/Acronym/Agency:
HD046861/HD/NICHD NIH HHS; HD059961/HD/NICHD NIH HHS; R01 HD046861/HD/NICHD NIH HHS
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