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Fetal Heart Rate Predictors of Long QT Syndrome.
MedLine Citation:
PMID:  23124029     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Fetal long QT syndrome (LQTS) is associated with complex arrhythmias including torsades de pointes and 2° atrioventricular (AV) block. Sinus bradycardia has also been associated with fetal LQTS, but little is known of this rhythm manifestation. Our purpose was to characterize the fetal heart rate (FHR)/gestational age (GA) profile of fetal LQTS. METHODS AND RESULTS: We ascertained fetal LQTS subjects by family history (Group 1) or fetal arrhythmia referral (Group 2). We compared FHR in LQTS subjects vs. normal fetuses. To identify FHR predictors of LQTS, we calculated a "bradycardia index" as % of LQTS FHR recordings either ≤ 110 bpm (obstetrical standard) or ≤ 3rd percentile for GA. Among 42 LQTS subjects, 26 were in Group 1 and 16 in Group 2. There were 536 normal fetuses. The bradycardia index was only 15% for FHR≤110 bpm, but 66% for FHR ≤ 3rd percentile for GA. Ten fetuses with complex arrhythmias also had severe and sustained sinus bradycardia throughout gestation. Identifying a fetal proband in Group 2 resulted in LQTS diagnosis in 9 unsuspected members of 6 families. CONCLUSIONS: FHR varies by GA in both normal and LQTS fetuses. Postnatal evaluation of neonates with FHR ≤3rd percentile for GA may improve ascertainment of LQTS in fetuses, neonates and undiagnosed family members.
Authors:
Jason L Mitchell; Bettina F Cuneo; Susan P Etheridge; Hitoshi Horigome; Hsin-Yi Weng; D Woodrow Benson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-2
Journal Detail:
Title:  Circulation     Volume:  -     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 The Heart Institute for Children, Oak Lawn, IL;
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