Document Detail

Fetal HLA typing in beta thalassaemia: implications for haemopoietic stem-cell transplantation.
MedLine Citation:
PMID:  12853199     Owner:  NLM     Status:  MEDLINE    
Stem-cell transplantation can cure beta thalassaemia. We aimed to assess whether fetal HLA typing done early in the pregnancy of couples who were at risk of beta thalassaemia could provide an alternative to pregnancy termination if the prospect of a bone-marrow transplantation from a family member was available. In our clinic in Sardinia, we did fetal HLA typing for 49 couples at risk of having a baby with beta thalassaemia. Two affected children were born and successfully received a transplantation from a family donor. Five non-affected fetuses were HLA compatible with an affected sibling and their cord blood was harvested for a future transplantation.
Maria Grazia Orofino; Francesca Argiolu; Maria Adele Sanna; Maria Cristina Rosatelli; Teresa Tuveri; Maria Teresa Scalas; Manuela Badiali; Paola Cossu; Rosalba Puddu; Maria Eliana Lai; Antonio Cao
Related Documents :
2659109 - Mechanism of graft failure in hla-matched and hla-mismatched bone marrow transplant rec...
18454999 - Renal transplantation in mapuche people.
331569 - Studies on the strength of hla antigens in related donor kidney transplants.
2586129 - Independent risk factors predicting acute graft rejection in cardiac transplant recipie...
3276369 - Triple therapy in cadaver renal transplantation.
16684959 - Optimization of conditioning for marrow transplantation from unrelated donors for patie...
10347989 - Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloabl...
15055789 - Ultrasonographic features of focal xanthogranulomatous pyelonephritis.
8753669 - Growth of the solitary kidney after nephrectomy in children with unilateral wilms' tumor.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  362     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-10     Completed Date:  2003-07-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-2     Citation Subset:  AIM; IM    
Universita degli Studi di Cagliari, Department of Biomedical Science and Biotechnology, Paediatric Clinic of the Bone Marrow Transplant Centre, Cagliari, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fetal Diseases / diagnosis,  immunology*,  therapy
Genetic Counseling
Hematopoietic Stem Cell Transplantation*
Histocompatibility Testing* / ethics
Prenatal Diagnosis / ethics
Risk Factors
beta-Thalassemia / diagnosis,  immunology*,  therapy*
Comment In:
Lancet. 2003 Jul 5;362(9377):6   [PMID:  12853191 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH.
Next Document:  Effect on dyspnoea and hypoxaemia of inhaled N(G)-nitro-L-arginine methyl ester in hepatopulmonary s...