Document Detail


Fetal genotype for the xenobiotic metabolizing enzyme NQO1 influences intrauterine growth among infants whose mothers smoked during pregnancy.
MedLine Citation:
PMID:  20331656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal smoking during pregnancy retards fetal growth and depresses infant birth weight. The magnitude of these effects may be moderated by fetal genotype. The current study investigated maternal smoking, fetal genotype, and fetal growth in a large population sample of dizygotic twins. Maternal smoking retarded fetal growth in a dose-dependent fashion. In a subsample of 497 twin pairs whose mothers smoked during pregnancy, a functional polymorphism in the NAD(P)H:quinone oxidoreductase gene (NQO1 Pro187Ser; rs1800566) was significantly associated with fetal growth within families. The effect was strongest among moderate smokers. This is the first demonstration that fetal genotype for an enzyme involved in tobacco smoke metabolism influences intrauterine growth independent of maternal genotype. Future studies should conduct formal tests of Fetal Genotype x Maternal Smoking interactions.
Authors:
Thomas S Price; Tilo Grosser; Robert Plomin; Sara R Jaffee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Child development     Volume:  81     ISSN:  1467-8624     ISO Abbreviation:  Child Dev     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-08-04     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0372725     Medline TA:  Child Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Fetal Development / genetics*,  physiology
Fetal Growth Retardation / etiology,  genetics*
Fetus / metabolism*
Genotype
Humans
Infant, Newborn
Male
Maternal Exposure / adverse effects
Mothers*
NAD(P)H Dehydrogenase (Quinone) / genetics*
Polymorphism, Genetic
Pregnancy
Smoking / adverse effects*
Twins, Dizygotic / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
G0500079//Medical Research Council
Chemical
Reg. No./Substance:
EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2/NQO1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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