| Fetal epigenetic mechanisms and innate immunity in asthma. | |
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MedLine Citation:
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PMID: 20820961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allergy and asthma are chronic inflammatory diseases that result from complex gene-environment interactions. Recent evidence points to the importance of prenatal and postnatal developmental processes in the maturation of balanced immune responses. Novel data indicate that epigenetic mechanisms contribute to the development of T-helper-cell function. Environmental factors, including diesel exhaust particles, vitamins, and tobacco smoke, operate through such mechanisms. Furthermore, the role of environmental microbes provides another-and maybe an even more important-group of exogenous exposures that operate in this critical time frame. A better understanding of fetal immuno-maturation conditions will provide the basis for the development of novel allergo-protective clinical strategies. |
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Authors:
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Petra Ina Pfefferle; Olaf Pinkenburg; Harald Renz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current allergy and asthma reports Volume: 10 ISSN: 1534-6315 ISO Abbreviation: Curr Allergy Asthma Rep Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101096440 Medline TA: Curr Allergy Asthma Rep Country: United States |
Other Details:
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Languages: eng Pagination: 434-43 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
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etiology,
immunology*,
physiopathology Epigenesis, Genetic / immunology* Female Fetal Development / immunology* Fetus / immunology*, physiopathology Humans Immunity, Innate* Male Maternal Exposure / adverse effects Pregnancy Prenatal Exposure Delayed Effects / etiology, immunology, physiopathology T-Lymphocytes, Helper-Inducer / immunology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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