Document Detail

Fetal brain hemodynamic changes in intrauterine transfusion: influence of needle puncture site.
MedLine Citation:
PMID:  19752525     Owner:  NLM     Status:  In-Process    
OBJECTIVES: Previous research has suggested that hemodynamic changes after in utero transfusion may be related to fetal stress. We tested the hypothesis that these hemodynamic changes are more pronounced when the needle is inserted in the fetal abdomen compared with the umbilical cord root. METHODS: Most intrauterine transfusions are performed by inserting a needle either in the umbilical cord root at the placental surface (PCI) or in the intrahepatic portion of the umbilical vein (IHV). We analyzed prospectively collected data of all intrauterine blood transfusions (IUT) for fetal alloimmune anemia (from 2000 to 2003), for which complete data were available on needling site and middle cerebral artery (MCA) Doppler flow velocity measurements before and immediately after the procedure. RESULTS: Data of 57 IUTs were included. In 32 patients, the transfusion was performed through the PCI and in 25 patients through the IHV. Mean pulsatility index (PI) in the PCI group was 2.0 before and 1.7 after IUT (p = 0.011), and in the IHV group 1.9 before and 1.5 after IUT (p = 0.001). In both groups, MCA PI decreased significantly, but there was no difference in decrease between the two groups (p = 0.99). CONCLUSIONS: In anemic fetuses undergoing transfusion, the observed fetal brain hemodynamic changes were independent of the site of needle insertion. The decrease in fetal MCA PI is therefore likely to be caused by the volume expansion.
P N Adama van Scheltema; S Borkent; E Sikkel; D Oepkes; F P H A Vandenbussche
Related Documents :
3932635 - Contribution of the bohr effect to the fall in fetal po2 caused by maternal alkalosis.
2196495 - Uterine and fetal doppler flow changes from a single dose of a long-acting intranasal d...
2468895 - The effect of nitrendipine (nit) on maternal and fetal blood pressure, uterine blood fl...
2101405 - Effects of chronic instrumentation on fetal growth.
18071275 - Assessment of cerebrovascular reserve before and after sta-mca bypass surgery by spect ...
25375595 - Lateral migration of a spherical capsule near a plane wall in stokes flow.
Publication Detail:
Type:  Journal Article     Date:  2009-09-11
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  26     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  131-3     Citation Subset:  IM    
Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  FGFR3 gene mutations in Chinese cases of thanatophoric dysplasia type 1.
Next Document:  Pregnancy Outcome in Maternal Crigler-Najjar Syndrome Type II: A Case Report and Systematic Review o...