Document Detail


Fetal atrioventricular block and postpartum augmentative QT prolongation in a patient with long-QT syndrome with KCNQ1 mutation.
MedLine Citation:
PMID:  20487114     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The case of a 32-year-old pregnant woman, who had had several syncopal episodes during swimming and running at 9 and 10 years of age and whose fetus had 2:1 AV block, is presented. The mother and baby had the same heterozygous single nucleotide substitution in KCNQ1 at T587M. After 27 weeks of gestation, the fetal 2:1 AV block disappeared, and 1:1 AV conduction resumed, with a fetal heart rate of 110-120 beats/min. The maternal electrocardiogram revealed a normal QTc interval (433 ms) without ST-T abnormalities at gestational week 23, but the QTc was 490 and 531 ms at 1 and 2 months postpartum, with biphasic T waves in leads V2 and V3. This case is the first report of fetal 2:1 AV block with KCNQ1 mutation (T587M) and unmasked maternal QT prolongation in the postpartum period.
Authors:
Hiroshi Furushima; Masaomi Chinushi; Akinori Sato; Yoshifusa Aizawa; Akira Kikuchi; Koichi Takakuwa; Kenichi Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  21     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1170-3     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
Affiliation:
First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori, Niigata, Japan. chimiri@med.niigata-u.ac-jp
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