| Fetal atrioventricular block and postpartum augmentative QT prolongation in a patient with long-QT syndrome with KCNQ1 mutation. | |
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MedLine Citation:
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PMID: 20487114 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The case of a 32-year-old pregnant woman, who had had several syncopal episodes during swimming and running at 9 and 10 years of age and whose fetus had 2:1 AV block, is presented. The mother and baby had the same heterozygous single nucleotide substitution in KCNQ1 at T587M. After 27 weeks of gestation, the fetal 2:1 AV block disappeared, and 1:1 AV conduction resumed, with a fetal heart rate of 110-120 beats/min. The maternal electrocardiogram revealed a normal QTc interval (433 ms) without ST-T abnormalities at gestational week 23, but the QTc was 490 and 531 ms at 1 and 2 months postpartum, with biphasic T waves in leads V2 and V3. This case is the first report of fetal 2:1 AV block with KCNQ1 mutation (T587M) and unmasked maternal QT prolongation in the postpartum period. |
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Authors:
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Hiroshi Furushima; Masaomi Chinushi; Akinori Sato; Yoshifusa Aizawa; Akira Kikuchi; Koichi Takakuwa; Kenichi Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular electrophysiology Volume: 21 ISSN: 1540-8167 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 1170-3 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley Periodicals, Inc. |
Affiliation:
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First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori, Niigata, Japan. chimiri@med.niigata-u.ac-jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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