Document Detail


Ferulic acid protects lymphocytes from radiation-predisposed oxidative stress through extracellular regulated kinase.
MedLine Citation:
PMID:  21043551     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose: The objective of this study was to investigate the radioprotective effect of ferulic acid (FA) on irradiated lymphocytes and discover the possible mechanisms of protection. Materials and methods: Lymphocytes were pretreated for 12 h with FA (0.001-0.1 μM) and then exposed to 3 Gy radiation. Cell apoptosis, intracellular reactive oxygen species (ROS), and signal pathway was analysed. Results: Irradiation increased cell death, DNA fragmentation and intracellular ROS. Pretreatment with FA significantly reversed this tendency and attenuated the irradiation-induced ROS generation. Furthermore, several anti-apoptotic characteristics of FA were determined, including the ability to diminish cytosolic Ca(2+) concentration, inhibit caspase-3 activation and cytochrome c translocation, upregulate B-cell lymphoma 2 (Bcl-2) and downregulate Bcl-2-associated X protein (Bax) in 3 Gy-irradiated lymphocytes. Signal pathway analysis showed FA decreased the activation of extracellular regulated kinase (ERK), which had been activated by radiation. Conclusion: The results suggest that FA had a radioprotective effect through the ERK pathway to inhibit apoptosis and oxidation, and it may be an effective candidate for treating radiation diseases associated with oxidative stress.
Authors:
Zeng-Chun Ma; Qian Hong; Yu-Guang Wang; Hong-Ling Tan; Cheng-Rong Xiao; Qian-De Liang; Dong-Gen Wang; Yue Gao
Publication Detail:
Type:  Journal Article     Date:  2010-11-02
Journal Detail:
Title:  International journal of radiation biology     Volume:  87     ISSN:  1362-3095     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  130-40     Citation Subset:  IM; S    
Affiliation:
Beijing Institute of Radiation Medicine, Beijing, P. R. China.
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