| Ferulic acid protects lymphocytes from radiation-predisposed oxidative stress through extracellular regulated kinase. | |
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MedLine Citation:
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PMID: 21043551 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: The objective of this study was to investigate the radioprotective effect of ferulic acid (FA) on irradiated lymphocytes and discover the possible mechanisms of protection. Materials and methods: Lymphocytes were pretreated for 12 h with FA (0.001-0.1 μM) and then exposed to 3 Gy radiation. Cell apoptosis, intracellular reactive oxygen species (ROS), and signal pathway was analysed. Results: Irradiation increased cell death, DNA fragmentation and intracellular ROS. Pretreatment with FA significantly reversed this tendency and attenuated the irradiation-induced ROS generation. Furthermore, several anti-apoptotic characteristics of FA were determined, including the ability to diminish cytosolic Ca(2+) concentration, inhibit caspase-3 activation and cytochrome c translocation, upregulate B-cell lymphoma 2 (Bcl-2) and downregulate Bcl-2-associated X protein (Bax) in 3 Gy-irradiated lymphocytes. Signal pathway analysis showed FA decreased the activation of extracellular regulated kinase (ERK), which had been activated by radiation. Conclusion: The results suggest that FA had a radioprotective effect through the ERK pathway to inhibit apoptosis and oxidation, and it may be an effective candidate for treating radiation diseases associated with oxidative stress. |
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Authors:
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Zeng-Chun Ma; Qian Hong; Yu-Guang Wang; Hong-Ling Tan; Cheng-Rong Xiao; Qian-De Liang; Dong-Gen Wang; Yue Gao |
Publication Detail:
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Type: Journal Article Date: 2010-11-02 |
Journal Detail:
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Title: International journal of radiation biology Volume: 87 ISSN: 1362-3095 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: England |
Other Details:
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Languages: eng Pagination: 130-40 Citation Subset: IM; S |
Affiliation:
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Beijing Institute of Radiation Medicine, Beijing, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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