Document Detail


Ferulic acid prevents the injury-induced decrease of γ-enolase expression in brain tissue and HT22 cells.
MedLine Citation:
PMID:  24707299     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Ferulic acid is known to act as a protective agent in cerebral ischemia through its anti-oxidant activity. γ-Enolase is a neuron-specific enolase that also exerts a neuroprotective effect. Here, we investigated whether ferulic acid regulates the expression level of γ-enolase in middle cerebral artery occlusion (MCAO)-induced brain injury and glutamate exposure-induced neuronal cell death. Adult male rats were treated with either vehicle or ferulic acid (100 mg/kg, i.v.) after MCAO and cerebral cortex tissues were collected 24 h after MCAO. Using a proteomics approach, we found that γ-enolase expression was decreased in MCAO-injured animals treated with vehicle alone, whereas ferulic acid treatment attenuated this decrease. Reverse-transcription PCR and Western blot analyses confirmed that ferulic acid treatment prevented MCAO injury-induced decrease in γ-enolase. Furthermore, in hippocampal-derived cell lines, glutamate exposure also decreased γ-enolase expression and ferulic acid treatment attenuated this glutamate-induced decrease in γ-enolase. These findings suggest that ferulic acid mediates a neuroprotective effect by attenuating injury-induced decreases of γ-enolase expression in neuronal cells.
Authors:
Sang-A Gim; Phil-Ok Koh
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Publication Detail:
Type:  Journal Article     Date:  2014-03-24
Journal Detail:
Title:  Laboratory animal research     Volume:  30     ISSN:  1738-6055     ISO Abbreviation:  Lab Anim Res     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-04-07     Completed Date:  2014-04-07     Revised Date:  2014-04-09    
Medline Journal Info:
Nlm Unique ID:  101560684     Medline TA:  Lab Anim Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  -    
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