| Ferulic acid potentiates pentobarbital-induced sleep via the serotonergic system. | |
| | |
MedLine Citation:
|
PMID: 22897877 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) is a widely distributed natural phenolic compound that is abundant in many plant tissues and foods. This study investigated possible mechanisms underlying the sedative-hypnotic effect of FA through behavioral pharmacology methods. FA showed dose-dependent sedative effects on locomotion activity in normal mice. FA also significantly potentiated pentobarbital-induced (45mg/kg, i.p.) sleep by prolonging sleeping time and shortening sleep latency in a dose-dependent manner. These effects were augmented by the administration of 5-hydroxytryptophan (5-HTP), a precursor of 5-hydroxytryptamine (5-HT). With a sub-hypnotic dose of pentobarbital (25mg/kg, i.p.), FA significantly increased the rate of sleep onset and exhibited a synergistic effect with 5-HTP (2.5mg/kg, i.p.). Pretreatment with p-chlorophenylalanine (PCPA, an inhibitor of tryptophan hydroxylase) significantly decreased the duration of pentobarbital-induced sleep, whereas FA significantly reversed this effect. These results suggest that FA has sedative-hypnotic activity, possibly mediated by the serotonergic system. |
| | |
Authors:
|
Yue Tu; Shi-Xiang Cheng; Hong-Tao Sun; Tie-Zhu Ma; Sai Zhang |
Related Documents
:
|
12665277 - The cusp of carabelli: frequency, distribution, size and clinical significance in nigeria. 10371917 - Displacement of mandibular removable partial denture bases by tongue movements during s... 2216387 - Clinical factors associated with ledged canals in maxillary and mandibular molars. 1577337 - Footprint parameters as a measure of arch height. 11377897 - Assessment of anterior chamber flare and cells after laser in situ keratomileusis. 8500337 - Corneal asphericity and visual function after radial keratotomy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-7 |
Journal Detail:
|
Title: Neuroscience letters Volume: - ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Department of Brain, Affiliated Hospital of Logistics College of Chinese People's Armed Police Forces, Chenglin Road No. 220, Hedong District, Tianjin 300162, China; Tianjin Medical University, Yuquan Road No. 88, Nankai District, Tianjin 300193, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neural mismatch indices of vowel discrimination in monolingually and bilingually exposed infants: do...
Next Document: Transcriptional data: a new gateway to drug repositioning?