| Ferulic acid is nephrodamaging while gallic acid is renal protective in long term treatment of chronic kidney disease. | |
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MedLine Citation:
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PMID: 22154988 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUNDS & AIMS: The long term therapeutic effect of ferulic acid (FA) and gallic acid (GA) in treatment of chronic kidney disease (CKD) has been lacking. METHODS: Doxorubicin (DR, Adriamycin)-induced CKD rat model was established for this study. RESULTS: DR significantly reduced levels of serum albumin, GOT, GPT, RBC, TNF-α, and urinary creatinine and elevated serum cholesterol, TG, BUN, creatinine, uric acid, WBC, platelet count, and IL-6. In DRCKD rats, FA and GA significantly increased kidney weight and glomerular volume. FA reduced glomerular filtration rate but GA did not. FA enhanced more collagen deposition than GA in renal cortex and glomeruli. Both FA and GA showed crucial hyperlipidemic activity. The inhibitory effects of FA and GA on MMP-2 were very comparable. GA suppressed MMP-2 more effectively than FA in DRCKD rats. Both FA and GA induced SOD elevation and MDA elimination. In DRCKD rats, Western blot analysis indicated that FA further up-regulated CD34, α-SMA, tissue pDGFR, p-PDGFR, and TGF-β; and down-regulated p-PI3K, and p-Akt. Since both PDGF-BB and TGF-β are considered to induce kidney prefibrosis stage, GA was proved to be more beneficial in this regard. CONCLUSIONS: GA tends to protect the CKD while FA is not recommended for the long term CKD therapy. |
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Authors:
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Chiung-Chi Peng; Chiu-Lan Hsieh; Hui-Er Wang; Jin-Yuan Chung; Kuan-Chou Chen; Robert Y Peng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-9 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: - ISSN: 1532-1983 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Department of Physical Therapy, College of Health Care, China Medical University, 91 Hsueh-Shih Road, Taichung 40202, Taiwan, ROC; Graduate Institute of Rehabilitation Science, College of Health Care, China Medical University, 91 Hsueh-Shih Road, Taichung 40202, Taiwan, ROC; Taipei Medical University, 250, Wu-Xin St., Xin-Yi District, Taipei 110, Taiwan, ROC. |
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