Document Detail

Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats.
MedLine Citation:
PMID:  23188120     Owner:  NLM     Status:  Publisher    
ABSTRACT:: Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young L-NAME-treated Wistar rats and 10 month old spontaneously hypertensive rats (SHR) alone and following chronic treatment with ferulic acid (50 mg/kg/day); n=6-10; *p<0.05. Systolic blood pressures were increased following L-NAME treatment (control 125±2 mmHg, L-NAME 205±6* mmHg after 8 weeks) and in SHR (250±2 mmHg; WKY 149±4 mmHg). Hypertensive rats developed left ventricular (LV) hypertrophy, increased ventricular diastolic stiffness (κ; Wistar, 21.4±1.6; L-NAME, 30.1±0.9*; WKY, 24.1±0.9; SHR 29.5±0.7) and fibrosis of heart and kidneys. Treatment with ferulic acid reduced systolic blood pressure (L-NAME+ferulic acid, 157±4*; SHR+ferulic acid 214±8* mmHg), reduced left ventricular diastolic stiffness (L-NAME+ferulic acid, 25.2±0.5*; SHR+ferulic acid 26.3±0.5*) and attenuated inflammatory cell infiltration, ferric iron accumulation and collagen deposition in left ventricles and kidneys. Ferulic acid improved both endothelium-dependent relaxation in isolated thoracic aortic rings and antioxidant status by increasing SOD and catalase activity in heart and kidneys. Ferulic acid decreased plasma liver enzyme activities and plasma creatinine concentrations. Thus, ferulic acid improved the structure and function of the heart, blood vessels, liver and kidneys in hypertensive rats.
Md Ashraful Alam; Conrad Sernia; Lindsay Brown
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-26
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1School of Biomedical Sciences, The University of Queensland 4072, Australia 2Department of Biological and Physical Sciences, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
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