Document Detail

Ferulic acid, an efficient inhibitor of type B trichothecene biosynthesis and Tri gene expression in Fusarium liquid cultures.
MedLine Citation:
PMID:  19249362     Owner:  NLM     Status:  MEDLINE    
The effect of ferulic acid, the most abundant phenolic acid in wheat bran, was studied in vitro on type B trichothecene biosynthesis by Fusarium. It was demonstrated that ferulic acid is an efficient inhibitor of mycotoxin production by all strains of Fusarium tested, including different chemotypes and species. To analyse the mechanism of toxin biosynthesis inhibition by ferulic acid, expression of representative Tri genes, involved in the trichothecene biosynthesis pathway, was monitored by real-time RT-PCR. A decrease in the level of Tri gene expression was measured, suggesting that inhibition of toxin synthesis by ferulic acid could be regulated at the transcriptional level. Moreover, toxin production was shown to be reduced proportionally to the initial amount of ferulic acid added in the culture medium. Addition of ferulic acid either at the spore germination step or to a mycelial culture resulted in the same final inhibitory effect on mycotoxin accumulation. A cumulative inhibitory effect on trichothecene biosynthesis was even observed with successive supplementation of ferulic acid. Ferulic acid, which content varies among wheat varieties, could then play an important role in modulating trichothecene biosynthesis by Fusarium in some wheat varieties.
Anne-Laure Boutigny; Christian Barreau; Vessela Atanasova-Penichon; Marie-Noëlle Verdal-Bonnin; Laëtitia Pinson-Gadais; Florence Richard-Forget
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-26
Journal Detail:
Title:  Mycological research     Volume:  113     ISSN:  1469-8102     ISO Abbreviation:  Mycol. Res.     Publication Date:    2009 Jun-Jul
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-06-12     Revised Date:  2009-06-16    
Medline Journal Info:
Nlm Unique ID:  8913481     Medline TA:  Mycol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  746-53     Citation Subset:  IM    
Institut de Recherches Technologiques Agroalimentaires des Céréales, 66 rue La Boëtie, 75008 Paris, France.
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MeSH Terms
Biosynthetic Pathways / drug effects
Coumaric Acids / pharmacology*
Culture Techniques
Fungal Proteins / genetics*,  metabolism
Fusarium / drug effects*,  genetics,  metabolism
Gene Expression / drug effects*
Trichothecenes / antagonists & inhibitors,  biosynthesis*
Reg. No./Substance:
0/Coumaric Acids; 0/Fungal Proteins; 0/Trichothecenes; 1135-24-6/ferulic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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