| Fertilization outcome, embryo development and birth after unstimulated IVM. | |
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MedLine Citation:
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PMID: 20924665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: IVM oocytes were collected 36 h post hCG and matured in vitro for 28-30 h. All oocytes were inseminated by ICSI. Resulting zygotes and embryos were assessed on day-1, 2 and 3, when transfers were made. RESULTS: The overall oocyte maturation and fertilization rates were 63% and 62%, respectively. Abnormal fertilization rate was 27%. [corrected] Ninety five and 14.6% of the 2Pn zygotes reached the 2-cell and 8-cell stage at day-2 and day-3, respectively. Embryo quality assessment on day-3 at transfer revealed that only 9% of the embryos were of very good quality. Most embryos showed developmental delay. An average of 3.29 embryos were transferred per patient resulting in implantation and clinical gestation rates of 16% and 32%, respectively. Overall 14 healthy babies were born and there is one ongoing pregnancy. CONCLUSION: Results show a significant rate of abnormal fertilization and poor embryo quality after IVM, which is reflected in a higher than average number of embryos being transferred. However, pregnancy, implantation and birth rates are reasonably high and allow us to consider IVM a valuable approach for the treatment of infertility in PCO or PCOS patients. |
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Authors:
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Adriana Bos-Mikich; Marcelo Ferreira; Marcos Höher; Gerta Frantz; Norma Oliveira; Caroline G Dutra; Nilo Frantz |
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Publication Detail:
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Type: Journal Article Date: 2010-10-06 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 28 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-18 Completed Date: 2011-07-08 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 107-10 Citation Subset: IM |
Affiliation:
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Department of Morphological Sciences, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, CEP: 90.050-170. adriana.bosmikich@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Embryo Implantation / physiology Embryonic Development Female Fertilization in Vitro* Humans Infertility, Female / therapy* Oocytes / cytology, growth & development* Oogenesis Parturition* Pregnancy Pregnancy Rate Sperm Injections, Intracytoplasmic Treatment Outcome Zygote / growth & development |
| Comments/Corrections | |
Erratum In:
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J Assist Reprod Genet. 2012 Aug;29(8):857 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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