Document Detail


Fertilization outcome, embryo development and birth after unstimulated IVM.
MedLine Citation:
PMID:  20924665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/PURPOSES: A common observation in oocyte in vitro maturation (IVM) cycles is poor embryo quality. However, no study was dedicated to assess zygote and early cleavage embryo quality in IVM cycles. The objective of this study is to analyze fertilization outcome, embryo development and the resulting pregnancy and births in unstimulated IVM cycles.
METHODS: IVM oocytes were collected 36 h post hCG and matured in vitro for 28-30 h. All oocytes were inseminated by ICSI. Resulting zygotes and embryos were assessed on day-1, 2 and 3, when transfers were made.
RESULTS: The overall oocyte maturation and fertilization rates were 63% and 62%, respectively. Abnormal fertilization rate was 27%. [corrected] Ninety five and 14.6% of the 2Pn zygotes reached the 2-cell and 8-cell stage at day-2 and day-3, respectively. Embryo quality assessment on day-3 at transfer revealed that only 9% of the embryos were of very good quality. Most embryos showed developmental delay. An average of 3.29 embryos were transferred per patient resulting in implantation and clinical gestation rates of 16% and 32%, respectively. Overall 14 healthy babies were born and there is one ongoing pregnancy.
CONCLUSION: Results show a significant rate of abnormal fertilization and poor embryo quality after IVM, which is reflected in a higher than average number of embryos being transferred. However, pregnancy, implantation and birth rates are reasonably high and allow us to consider IVM a valuable approach for the treatment of infertility in PCO or PCOS patients.
Authors:
Adriana Bos-Mikich; Marcelo Ferreira; Marcos Höher; Gerta Frantz; Norma Oliveira; Caroline G Dutra; Nilo Frantz
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Publication Detail:
Type:  Journal Article     Date:  2010-10-06
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  28     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-18     Completed Date:  2011-07-08     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
Affiliation:
Department of Morphological Sciences, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, CEP: 90.050-170. adriana.bosmikich@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Embryo Implantation / physiology
Embryonic Development
Female
Fertilization in Vitro*
Humans
Infertility, Female / therapy*
Oocytes / cytology,  growth & development*
Oogenesis
Parturition*
Pregnancy
Pregnancy Rate
Sperm Injections, Intracytoplasmic
Treatment Outcome
Zygote / growth & development
Comments/Corrections
Erratum In:
J Assist Reprod Genet. 2012 Aug;29(8):857

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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