Document Detail

Fertility treatment in the forty and older woman.
MedLine Citation:
PMID:  11808844     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the outcomes and logical progression of fertility treatment in women forty years and older using their own oocytes.
METHODS: This was a retrospective study in which 401 completed treatment cycles in 152 women aged forty and older were reviewed.
RESULTS: Assisted reproductive technology (ART) cycles (n = 58) were reviewed, comprising both in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT). Intrauterine insemination (IUI) cycles (n = 343) were reviewed, consisting of 38 unstimulated natural cycle-IUI (NC-IUI), 194 clomiphene citrate-IUI (CC-IUI), and 111 injectable gonadotropins-IUI (INJ-IUI) cycles. The live birth rate of 15.5% for ART cycles was significantly higher than the live birth rate of 3.2% seen for all IUI cycles (p = 0.0007). There were no differences among treatment groups in spontaneous abortion, preterm delivery, or ectopic pregnancy rates.
CONCLUSIONS: For women > or = 40 years of age who wish to use their own eggs, ART offers the best chances for conception and delivery.
A Auyeung; M E Klein; V S Ratts; R R Odem; D B Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  18     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-25     Completed Date:  2002-09-04     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  638-43     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63108-2259, USA.
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MeSH Terms
Clomiphene / pharmacology*,  therapeutic use
Fertility Agents, Female / pharmacology*,  therapeutic use
Fertilization in Vitro*
Gamete Intrafallopian Transfer
Gonadotropins / pharmacology*,  therapeutic use
Infertility, Female / therapy*
Middle Aged
Pregnancy Outcome
Reg. No./Substance:
0/Fertility Agents, Female; 0/Gonadotropins; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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