| Fertility-sparing surgery for persistent gestational trophoblastic neoplasia in the myometrium: a case report. | |
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MedLine Citation:
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PMID: 17583247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Persistently low-level "real" serum human chorionic gonadotropin (hCG) after treatment for gestational trophoblastic neoplasia (GTN) in patients desirous of preserving fertility is a diagnostic and management challenge. Among the possible explanations is the presence of false positive ("phantom") hCG or of trophoblasts in a myometrial sanctuary. CASE: An 18-year-old woman had persistent low-level hCG values in her serum after treatment for nonmetastatic GTN. Her only child had died, and she wanted to preserve her fertility potential. Phantom hCG was excluded. Positron emission tomography (PET) showed increased uptake in an area of the uterus in which magnetic resonance imaging had shown an ill-defined, ovoid lesion. Removal of the lesion with preservation of the uterus followed by 2 courses of multiagent chemotherapy (methotrexate, dactinomycin and cyclophosphamide) resuited in clinical remission. CONCLUSION: PET can prove useful in detecting persistent disease in a myometrial sanctuary in patients with resistant, nonmetastatic GTN. Conservative surgical excision with uterine preservation is possible and can be of value in achieving remission. |
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Authors:
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Luis Rojas-Espaillat; Karen L Houck; Enrique Hernandez; Ross S Berkowitz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 52 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-06-22 Completed Date: 2007-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 431-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antineoplastic Combined Chemotherapy Protocols Chorionic Gonadotropin / blood Combined Modality Therapy Diagnosis, Differential Female Fertility Gestational Trophoblastic Neoplasms / blood, diagnosis*, pathology, radiography, surgery Humans Myometrium Positron-Emission Tomography Pregnancy Uterine Neoplasms / blood, diagnosis*, pathology, radiography, surgery |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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