Document Detail


Fertility-sparing surgery in patients with cervical cancer.
MedLine Citation:
PMID:  20619737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are several types of fertility saving procedures that can be done in patients with cervical cancer, which differ in terms of surgical approach and extent of paracervical resection. This review assesses oncological and pregnancy results after different procedures. The oncological results of vaginal radical trachelectomies (VRT) and abdominal radical trachelectomies (ART) are similar for tumours less than 2 cm in size, and are now considered safe surgical procedures. Oncological outcomes of VRT and ART in tumours larger than 2 cm are also identical, but the results cannot be considered satisfactory. Preliminary findings of less radical procedures (ie, deep cone and simple trachelectomy) in patients with tumours less than 2 cm, and negative sentinel and other pelvic lymph nodes, are comparable with the results of VRT and ART. Downstaging tumours larger than 2 cm by neoadjuvant chemotherapy is still an experimental procedure and will need multicentre cooperation to verify its oncological safety. Pregnancy results vary statistically with the different methods.
Authors:
Lukas Rob; Petr Skapa; Helena Robova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-07-08
Journal Detail:
Title:  The Lancet. Oncology     Volume:  12     ISSN:  1474-5488     ISO Abbreviation:  Lancet Oncol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-03-14     Revised Date:  2014-08-18    
Medline Journal Info:
Nlm Unique ID:  100957246     Medline TA:  Lancet Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  192-200     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Disease Management
Female
Fertility*
Humans
Pregnancy
Treatment Outcome
Uterine Cervical Neoplasms / surgery*
Comments/Corrections
Comment In:
Lancet Oncol. 2011 May;12(5):422; author reply 422-3   [PMID:  21536222 ]
Erratum In:
Lancet Oncol. 2011 Jan;12(1):11

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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