| Fertility preservation in gestational trophoblastic disease. | |
| | |
MedLine Citation:
|
PMID: 22285526 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Most women with gestational trophoblastic disease are of reproductive age. Because the disease is readily treatable with favourable prognosis, fertility becomes an important issue. Hydatidiform mole is a relatively benign disease, and most women do not require chemotherapy after uterine evacuation. A single uterine evacuation has no significant effect on future fertility, and pregnancy outcomes in subsequent pregnancies are comparable to that of the general population, despite a slight increased risk of developing molar pregnancy again. If women develop persistent trophoblastic disease, single or combined chemotherapy will be needed. Although ovarian dysfunction after chemotherapy is a theoretical risk, a term live birth rate of higher than 70% has been reported without increased risk of fetal abnormalities. Successful pregnancies have also been reported after choriocarcinoma. Only a few case reports have been published on fertility-sparing treatment in placental-site trophoblastic tumour, and the successful rate is about 67%. Women are advised to refrain from pregnancy for at least 6 months after a molar pregnancy, and at least 12 months after a gestational trophoblastic neoplasia. Most of the contraceptive methods do not have an adverse effect on the return of fertility. Finally, at least one-half of these women suffer from some form of psychological or sexual problems. Careful counselling and involvement of a multi-disciplinary team are mandated. |
| | |
Authors:
|
K Y Tse; Hextan Y S Ngan |
Related Documents
:
|
12061536 - Effect of seminal plasma concentration and various extenders on postthaw motility and g... 10709936 - The importance of seminal plasma on the fertility of subsequent artificial insemination... 22332106 - Racial-ethnic differences in pregnancy-related weight. 22569946 - Changes in leisure time physical activity during pregnancy compared to the prior year. 10029256 - Electroencephalogram confirmatory rate in neonatal seizures. 6910716 - Effects of pregnancy on the febrile responses in sheep. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
|
Title: Best practice & research. Clinical obstetrics & gynaecology Volume: - ISSN: 1532-1932 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101121582 Medline TA: Best Pract Res Clin Obstet Gynaecol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Obstetrics and Gynaecology, Queen Mary Hospital, the University of Hong Kong, Hong Kong. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intensifying the microencapsulation process: Ultrasonic atomization as an innovative approach.
Next Document: A pediatric case of reversible cerebral vasoconstriction syndrome with cortical subarachnoid hemorrh...