Document Detail

Fertility preservation: a comprehensive approach to the young woman with cancer.
MedLine Citation:
PMID:  15784825     Owner:  NLM     Status:  MEDLINE    
Modern treatments for cancers of the reproductive age are yielding ever-higher cure rates, but more often than not, the price paid for survival is the loss of reproductive function from gonadal toxicity. Alkylating agents and ionizing radiation have well-recognized deleterious effects within the testes and ovary and cause sterility in a high proportion of patients exposed to these treatments. Preservation of fertility for men simply involves the banking of sperm before treatment, but for women, the storage of gametes is technically very complex and has limited success. Even when faced with the diagnosis of cancer, many reproductive-aged women are burdened by the possibility of never conceiving a child with their own eggs. Fertility preservation for the reproductive-age women with cancer is emerging as a challenging, but rewarding, application of assisted reproductive technologies such as in vitro fertilization. With recent advances in cryopreservation techniques, oocytes, embryos, and ovarian tissue can be banked from these patients before exposure to sterilizing chemotherapy and radiotherapy, providing future fertility options without compromising survival.
Jeffrey E Roberts; Kutluk Oktay
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the National Cancer Institute. Monographs     Volume:  -     ISSN:  1052-6773     ISO Abbreviation:  J. Natl. Cancer Inst. Monographs     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-23     Completed Date:  2005-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011255     Medline TA:  J Natl Cancer Inst Monogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-9     Citation Subset:  IM    
Center for Reproductive Medicine & Infertility, New York, NY 10021, USA.
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MeSH Terms
Age Factors
Antineoplastic Agents / adverse effects
Embryo Transfer*
Fertilization in Vitro*
Infertility, Female / etiology*,  prevention & control*
Neoplasms / drug therapy,  radiotherapy
Ovary / transplantation
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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