Document Detail


Fertility and outcomes of pregnancy after chemotherapy in a sample of childbearing aged women.
MedLine Citation:
PMID:  15482379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to review the characteristics and outcomes of pregnancies occurring in women of childbearing age after chemotherapy for malignant disease. Between November 1998 and October 1999, a total of 16 patients who were treated for ovary (three), mole (one), vaginal (one), breast (four), Hodgkin's disease (four), lung (one), melanoma (one) and osteosarcoma (one) carcinoma were identified and retrospectively questioned about their fertility status. All the 16 women included in this study received at least one alkylating agent. Five patients (31%) experienced anomalies of hormonal cycle during and after the treatment. All of them recovered normal cycle without consequence of fertility. Caesarean section was performed in seven of 20 (35%) pregnancies with known outcomes. No obstetrical events were reported. The 16 women had 21 pregnancies resulting in 18 normal infants, one newborn with a minor abnormality (tallus foot), one spontaneous abortion and one lost of follow-up to 6 months of pregnancy. The present survey suggests that cytotoxic drug exposure had no deleterious effects on subsequent pregnancies. A prospective and systemic survey would be the only means able to clarify the actual cancer therapy on reproductive outcome and to investigate the long-term effects in the progeny.
Authors:
G Durrieu; M Rigal; R Bugat; M Lapeyre-Mestre
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  18     ISSN:  0767-3981     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-14     Completed Date:  2005-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  573-9     Citation Subset:  IM    
Affiliation:
Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Faculté de Médecine, 37, Allées Jules Guesde, 31073 Toulouse Cx, France. durrieu@cict.fr
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / epidemiology,  etiology
Abortion, Spontaneous / epidemiology,  etiology
Adolescent
Adult
Antineoplastic Agents / administration & dosage,  adverse effects*,  therapeutic use
Antineoplastic Agents, Alkylating / administration & dosage,  adverse effects,  therapeutic use
Dose-Response Relationship, Drug
Female
Fertility / drug effects*
Humans
Infant, Newborn
Neoplasms / drug therapy*
Pregnancy
Pregnancy Complications, Neoplastic / drug therapy*
Pregnancy Outcome / epidemiology
Premature Birth / epidemiology,  etiology
Retrospective Studies
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antineoplastic Agents, Alkylating

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