Document Detail

Fertility in thalassemia: the Greek experience.
MedLine Citation:
PMID:  10091169     Owner:  NLM     Status:  MEDLINE    
Pregnancy in beta-thalassemic patients has become a not unusual event, especially in the last 10 years. The course and outcome of 19 pregnancies in 16 thalassemic women, followed in our unit, 12 with thalassemia major and 4 with thalassemia intermedia, were studied. Genetic counselling was provided and counselling regarding the planning or the continuation of the pregnancy was based mainly on cardiac performance at rest. Cardiac, endocrine and liver function were evaluated at baseline, monitored throughout pregnancy and reevaluated after delivery. Desferrioxamine treatment was discontinued as early as possible. During pregnancy the Hb level was maintained at about 10 g/dl in all women by transfusion. The course of pregnancy was essentially uneventful and elective Cesarean section was performed in all cases. The mean birth weight of the newborns was 3000 g. All babies were normal except for one with exomphalus. Pregnancy was well tolerated by the heart in all women and no endocrinological disorders were observed. In conclusion, pregnancies in beta-thalassemia can be safe for both mothers and their babies with careful selection and appropriate care.
M Karagiorga-Lagana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  11 Suppl 3     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  1998  
Date Detail:
Created Date:  1999-05-19     Completed Date:  1999-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  945-51     Citation Subset:  IM    
Thalassemia Unit, The Aghia Sophia Children's Hospital, Athens, Greece.
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MeSH Terms
Cesarean Section
Chelating Agents / administration & dosage
Deferoxamine / administration & dosage
Endocrine Glands / physiopathology
Heart / physiopathology
Infertility, Female / etiology*
Liver / physiopathology
Pregnancy Complications, Hematologic*
Pregnancy Outcome
beta-Thalassemia / complications*,  physiopathology
Reg. No./Substance:
0/Chelating Agents; 70-51-9/Deferoxamine

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