Document Detail

Fertility in intersubspecific hybrids of laboratory mice (Mus musculus domesticus) and molossinus mice (M. m. molossinus).
MedLine Citation:
PMID:  3240777     Owner:  NLM     Status:  MEDLINE    
We studied the reproductive performance of F1 and F2 hybrids of laboratory mice (C57BL/6, B6 and BALB/c) and molossinus mice (MOM and Mol-A). The F1 x F1 crosses were fully fertile. In the F2 x F2 crosses, the copulation rate was slightly lower and the pregnancy rate was markedly depressed: only 5 out of 18 copulated females (27.8%) became pregnant in the F2 hybrids derived from the reciprocal crosses of B6 x MOM, and in the F2 hybrids from BALB/c x Mol-A crosses, the pregnancy rate was 51.4% (18/35). This low fertility was attributed mainly to the F2 females, because there was a much lower pregnancy rate (56.5%; 26/46) in the (B6 x MOM)F2 female x B6 male crosses compared with the B6 female x (B6 x MOM)F2 male crosses (80.6%; 26/32). On the other hand, the pregnant F2 females were judged to have normal reproductive ability, based on observations of the numbers of corpora lutea, implantations and live fetuses at day 14 of pregnancy. Apparently there is segregation of fertile and sterile females at the F2 generation, but it remains to be determined how the loss of fertility is brought about in the sterile F2 females.
M Niwa; N Wakasugi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Jikken dobutsu. Experimental animals     Volume:  37     ISSN:  0007-5124     ISO Abbreviation:  Jikken Dobutsu     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-05-18     Completed Date:  1989-05-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1256412     Medline TA:  Jikken Dobutsu     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University, Aichi-ken, Japan.
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MeSH Terms
Hybridization, Genetic*
Mice / genetics,  physiology*

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