Document Detail

Fertility after discontinuation of treatment with an oral contraceptive containing 30 microg of ethinyl estradiol and 2 mg of dienogest.
MedLine Citation:
PMID:  16759929     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the conception rate after cessation of a combination of 30 microg ethinyl E2 and 2 mg dienogest (EE/DNG). DESIGN: Prospective observational study. SETTING: Population-based cohort in Germany. PATIENT(S): Women who wished to become pregnant after cessation of an oral contraceptive (EE/DNG). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Cumulative conception rate within 1 year after termination of EE/DNG and time to pregnancy. RESULT(S): After 1 year of follow-up, the cumulative pregnancy rate was 86.6% (full analysis set; n = 706). When all participants with complete data were analyzed (n = 652), the cumulative pregnancy rate was 94.0%. More than 15% of the patients conceived in each of the first three cycles after termination of EE/DNG; the mean time to pregnancy was 3.5 cycles. The preceding duration of treatment with EE/DNG did not influence the conception rate. Except in the youngest age group (16-18 years), a certain delay was observed in the other age groups. CONCLUSION(S): The present prospective study revealed only a slight delay in regaining fertility during the first three cycles after cessation of EE/DNG. Thereafter, the cumulative rate of conception did not differ from that observed in fertile women who attempted to become pregnant without prior contraception.
Inka Wiegratz; Katrin Mittmann; Horst Dietrich; Thomas Zimmermann; Herbert Kuhl
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  85     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-08     Completed Date:  2006-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1812-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, J. W. Goethe University, Frankfurt am Main, Germany.
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MeSH Terms
Age Distribution
Contraceptives, Oral, Combined
Contraceptives, Oral, Hormonal
Estrogens / administration & dosage
Ethinyl Estradiol / administration & dosage*
Fertility / drug effects*
Germany / epidemiology
Nandrolone / administration & dosage,  analogs & derivatives*
Outcome Assessment (Health Care)
Pregnancy Rate*
Risk Assessment
Risk Factors
Treatment Outcome
Withholding Treatment / statistics & numerical data*
Reg. No./Substance:
0/Contraceptives, Oral, Combined; 0/Contraceptives, Oral, Hormonal; 0/Estrogens; 434-22-0/Nandrolone; 57-63-6/Ethinyl Estradiol; 65928-58-7/dienogest

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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