| Fertility after discontinuation of treatment with an oral contraceptive containing 30 microg of ethinyl estradiol and 2 mg of dienogest. | |
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MedLine Citation:
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PMID: 16759929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the conception rate after cessation of a combination of 30 microg ethinyl E2 and 2 mg dienogest (EE/DNG). DESIGN: Prospective observational study. SETTING: Population-based cohort in Germany. PATIENT(S): Women who wished to become pregnant after cessation of an oral contraceptive (EE/DNG). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Cumulative conception rate within 1 year after termination of EE/DNG and time to pregnancy. RESULT(S): After 1 year of follow-up, the cumulative pregnancy rate was 86.6% (full analysis set; n = 706). When all participants with complete data were analyzed (n = 652), the cumulative pregnancy rate was 94.0%. More than 15% of the patients conceived in each of the first three cycles after termination of EE/DNG; the mean time to pregnancy was 3.5 cycles. The preceding duration of treatment with EE/DNG did not influence the conception rate. Except in the youngest age group (16-18 years), a certain delay was observed in the other age groups. CONCLUSION(S): The present prospective study revealed only a slight delay in regaining fertility during the first three cycles after cessation of EE/DNG. Thereafter, the cumulative rate of conception did not differ from that observed in fertile women who attempted to become pregnant without prior contraception. |
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Authors:
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Inka Wiegratz; Katrin Mittmann; Horst Dietrich; Thomas Zimmermann; Herbert Kuhl |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 85 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-08 Completed Date: 2006-06-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1812-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, J. W. Goethe University, Frankfurt am Main, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Contraceptives, Oral, Combined Contraceptives, Oral, Hormonal Estrogens / administration & dosage Ethinyl Estradiol / administration & dosage* Female Fertility / drug effects* Germany / epidemiology Humans Nandrolone / administration & dosage, analogs & derivatives* Outcome Assessment (Health Care) Pregnancy Pregnancy Rate* Risk Assessment Risk Factors Treatment Outcome Withholding Treatment / statistics & numerical data* |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Combined; 0/Contraceptives, Oral, Hormonal; 0/Estrogens; 434-22-0/Nandrolone; 57-63-6/Ethinyl Estradiol; 65928-58-7/dienogest |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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