Document Detail

Fertility and pregnancy outcome after abdominal irradiation that included or excluded the pelvis in childhood tumor survivors.
MedLine Citation:
PMID:  19632060     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate fertility after abdominal and/or pelvic irradiation in long-term female survivors. METHODS AND MATERIALS: Puberty and pregnancy outcome were analyzed in female survivors of childhood cancer (aged <18 years) treated with abdominal and/or pelvic radiotherapy (RT) at one of two French centers (Nancy and Lyon) between 1975 and 2004. Data were obtained from medical records and questionnaires sent to the women. RESULTS: A total of 84 patients who had received abdominal and/or pelvic RT during childhood and were alive and aged more than 18 years at the time of the study made up the study population. Of the 57 female survivors treated with abdominal RT that excluded the pelvis, 52 (91%) progressed normally through puberty and 23 (40%) had at least one recorded pregnancy. Of the 27 patients treated with pelvic RT, only 10 (37%) progressed normally through puberty and 5 (19%) had at least one recorded pregnancy. Twenty-two women (seventeen of whom were treated with pelvic RT) had certain subfertility. A total of 50 births occurred in 28 women, with one baby dying at birth; one miscarriage also occurred. There was a high prevalence of prematurity and low birth weight but not of congenital malformations. CONCLUSIONS: Fertility can be preserved in patients who undergo abdominal RT that excludes the pelvis, taking into account the other treatments (e.g., chemotherapy with alkylating agents) are taken into account. When RT includes the pelvis, fertility is frequently impaired and women can have difficulty conceiving. Nevertheless, pregnancies can occur in some of these women. The most important factor that endangers a successful pregnancy after RT is the total dose received by the ovaries and uterus. This radiation dose has to be systematically recorded to improve our ability to follow up patients.
H?l?ne Sudour; Pascal Chastagner; Line Claude; Emmanuel Desandes; Marc Klein; Christian Carrie; Valerie Bernier
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2009-07-23
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  76     ISSN:  1879-355X     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  867-73     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Department of Paediatric Onco-Hematology, CHU Nancy, Vandoeuvre-l?s-Nancy, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abdomen / radiation effects
Child, Preschool
Fertility / physiology,  radiation effects*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infertility, Female / etiology*,  prevention & control
Live Birth / epidemiology
Lymphatic Irradiation / adverse effects,  methods
Menstruation / physiology
Neoplasms / radiotherapy*
Ovary / radiation effects
Pelvis / radiation effects
Pregnancy Outcome*
Puberty / physiology,  radiation effects*
Radiotherapy Dosage
Retrospective Studies
Uterus / radiation effects
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cyclic vomiting syndrome: contribution to dysphagic infant death.
Next Document:  Translating response during therapy into ultimate treatment outcome: a personalized 4-dimensional MR...